Known targets — ChEMBL curated mechanism
FGFR1FGFR2FGFR3FGFR4FLT1FLT4KDRPDGFRAPDGFRB
The experimentally established mechanism targets of Morpholine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.33 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.33 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.33 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.33 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Morpholine SCHEMBL668275 | 0.98 | MEN1 (0.50) | MEN1KMT2AKDM4EGAACYP2C9 | |
| Morpholine SCHEMBL28395409 | 0.95 | MEN1 (0.48) | MEN1KMT2AKDM4EGAACYP2C9 | |
| Morpholine SCHEMBL28118007 | 0.95 | MEN1 (0.48) | MEN1KMT2AKDM4EGAACYP2C9 | |
| Morpholine SCHEMBL6941937 | 0.95 | MEN1 (0.48) | MEN1KMT2AKDM4EGAACYP2C9 | |
| Morpholine SCHEMBL28640639 | 0.93 | MEN1 (0.46) | MEN1KMT2AKDM4EGAACYP2C9 | |
| Morpholine SCHEMBL28565361 | 0.93 | MEN1 (0.46) | MEN1KMT2AKDM4EGAACYP2C9 | |
| Morpholine SCHEMBL29123850 | 0.91 | MEN1 (0.44) | MEN1KMT2AKDM4EGAACYP2C9 | |
| Morpholine SCHEMBL27977283 | 0.88 | MEN1 (0.41) | MEN1KMT2AKDM4EGAACYP2C9 | |
| Morpholine SCHEMBL15789446 | 0.85 | MEN1 (0.58) | MEN1KMT2AKDM4EGAACYP2C9 | |
| Morpholine SCHEMBL15789448 | 0.85 | MEN1 (0.58) | MEN1KMT2AKDM4EGAACYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109689730-A | Including TROGER alkali and isatin part and there is intrinsic micro porous polymer | 陶氏环球技术有限责任公司 | 2019-04-26 | — | — | CN | disclosed |
| EP-2293056-A2 | A method for analysing a metabolic pathway | Target Discovery, Inc. (US) | 2011-03-09 | — | — | EP | disclosed |
| EP-1194768-A4 | POLYPEPTIDE FINGERPRINTING METHODS, METABOLIC PROFILING, AND BIOINFORMATICS DATABASE | TARGET DISCOVERY INC (US) | 2008-03-26 | — | — | EP | disclosed |
| US-7211376-B2 | Polypeptide fingerprinting methods | TARGET DISCOVERY, INC. (US) | 2007-05-01 | — | — | US | disclosed |
| US-20050089930-A1 | Polypeptide fingerprinting methods | TARGET DISCOVERY, INC. (US) | 2005-04-28 | — | — | US | disclosed |
| US-6677114-B1 | HIGH RESOLUTION, PRECISION AND SENSITIVITY PROTEOMICS; MULTIDIMENSIONAL CAPILLARY ELECTROPHORESIS, MASS SPECTRO-GRAPHIC FRAGMENTATION AND PROTEIN SEQUENCE TAG IDENTIFICATION | TARGET DISCOVERY, INC. | 2004-01-13 | — | — | US | disclosed |
| EP-1194768-A1 | POLYPEPTIDE FINGERPRINTING METHODS, METABOLIC PROFILING, AND BIOINFORMATICS DATABASE | Target Discovery, Inc. (US) | 2002-04-10 | — | — | EP | disclosed |
| WO-2000063683-A1 | POLYPEPTIDE FINGERPRINTING METHODS, METABOLIC PROFILING, AND BIOINFORMATICS DATABASE | TARGET DISCOVERY, INC. (US) | 2000-10-26 | — | — | WO | disclosed |