Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | AKR1C3 | P42330 | 4/20 | 0.46 |
| ▸ | AKR1C2 | P52895 | 4/20 | 0.46 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.46 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.46 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.46 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | FBP1 | P09467 | 2/20 | 0.45 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.45 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.45 |
| ▸ | CDK2 | P24941 | 1/20 | 0.45 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.45 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.45 |
| ▸ | CASP3 | P42574 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16239257 | 0.86 | MAPT (0.50) | MAPTMEN1KMT2ARAB9ASMN1; SMN2 | |
| SCHEMBL14972557 | 0.83 | CTSV (0.59) | MAPTMEN1KMT2ASMN1; SMN2POLB | |
| SCHEMBL15087208 | 0.81 | L3MBTL1 (0.46) | MAPTHPGDMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL15091053 | 0.80 | NPC1 (0.50) | MAPTMEN1KMT2ARAB9ASMN1; SMN2 | |
| SCHEMBL14972507 | 0.80 | POLB (0.43) | MEN1KMT2ASMN1; SMN2CCNA2CDK2 | |
| SCHEMBL15091152 | 0.78 | MEN1 (0.41) | MAPTMEN1KMT2ARAB9ASMN1; SMN2 | |
| SCHEMBL14972511 | 0.77 | POLB (0.40) | MEN1KMT2ARAB9ASMN1; SMN2NPC1 | |
| SCHEMBL16174834 | 0.76 | MAPT (0.54) | MAPTHPGDMEN1KMT2ARAB9A | |
| SCHEMBL26906360 | 0.74 | MAPT (0.75) | MAPTHPGDMEN1KMT2ARAB9A | |
| SCHEMBL14972563 | 0.74 | MEN1 (0.44) | MAPTMEN1KMT2ARAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2631229-B1 | P2X4 RECEPTOR ANTAGONIST | NIPPON CHEMIPHAR CO (JP) | 2014-12-03 | — | — | EP | disclosed |
| US-8673915-B2 | P 2×4 receptor antagonist | NIPPON CHEMIPHAR CO., LTD. (JP) | 2014-03-18 | — | — | US | disclosed |
| EP-2631229-A1 | P2X4 RECEPTOR ANTAGONIST | Nippon Chemiphar Co., Ltd. (JP) | 2013-08-28 | — | — | EP | disclosed |
| US-20130178625-A1 | P 2 X 4 RECEPTOR ANTAGONIST | NIPPON CHEMIPHAR CO., LTD. (JP) | 2013-07-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130178625-A1 | P 2 X 4 RECEPTOR ANTAGONIST | P2RX4, P2RX2, P2RY4 | MAPT 4840/4885HPGD 1060/4885MEN1 3222/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.