Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | CASP3 | P42574 | 1/20 | 0.34 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.34 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.34 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL187255 | 0.83 | TDP1 (0.44) | MEN1KMT2ATDP1KDM4EL3MBTL1 | |
| SCHEMBL187572 | 0.83 | ALDH1A1 (0.48) | MEN1KMT2ATDP1KDM4EL3MBTL1 | |
| SCHEMBL8558796 | 0.75 | KMT2A (0.47) | MEN1KMT2ATDP1KDM4EL3MBTL1 | |
| SCHEMBL4158236 | 0.75 | MEN1 (0.47) | MEN1KMT2ATDP1KDM4EL3MBTL1 | |
| SCHEMBL2031745 | 0.73 | MEN1 (0.46) | MEN1KMT2ATDP1KDM4EL3MBTL1 | |
| SCHEMBL6073621 | 0.73 | MEN1 (0.43) | MEN1KMT2ATDP1KDM4EL3MBTL1 | |
| SCHEMBL15099897 | 0.73 | KDM4E (0.37) | KMT2AKDM4EL3MBTL1ALDH1A1SMN1; SMN2 | |
| SCHEMBL23272988 | 0.72 | KMT2A (0.49) | MEN1KMT2ATDP1KDM4EL3MBTL1 | |
| SCHEMBL29823182 | 0.72 | KMT2A (0.49) | MEN1KMT2ATDP1KDM4EL3MBTL1 | |
| SCHEMBL8094722 | 0.71 | MCHR1 (0.43) | MEN1KMT2ATDP1KDM4EL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10112928-B2 | Inhibitors of SYK | HOFFMANN-LA ROCHE INC. (US) | 2018-10-30 | — | — | US | disclosed |
| EP-2802567-B1 | PYRIDAZINE AMIDE COMPOUNDS AND THEIR USE AS SYK INHIBITORS | HOFFMANN LA ROCHE (CH) | 2017-03-01 | — | — | EP | disclosed |
| EP-2802567-B1 | PYRIDAZINE AMIDE COMPOUNDS AND THEIR USE AS SYK INHIBITORS | HOFFMANN LA ROCHE (CH) | 2017-03-01 | — | — | EP | disclosed |
| US-20150284367-A1 | INHIBITORS OF SYK | HOFFMANN-LA ROCHE INC. | 2015-10-08 | — | — | US | disclosed |
| US-20150284367-A1 | INHIBITORS OF SYK | HOFFMANN-LA ROCHE INC. | 2015-10-08 | — | — | US | disclosed |
| EP-2909174-A1 | INHIBITORS OF SYK | F. Hoffmann-La Roche AG (CH) | 2015-08-26 | — | — | EP | disclosed |
| US-8901124-B2 | Pyridazine amide compounds useful as SYK inhibitors | HOFFMANN-LA ROCHE INC. (US) | 2014-12-02 | — | — | US | disclosed |
| US-8901124-B2 | Pyridazine amide compounds useful as SYK inhibitors | HOFFMANN-LA ROCHE INC. (US) | 2014-12-02 | — | — | US | disclosed |
| EP-2802567-A1 | PYRIDAZINE AMIDE COMPOUNDS AND THEIR USE AS SYK INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2014-11-19 | — | — | EP | disclosed |
| WO-2014060371-A1 | INHIBITORS OF SYK | F. HOFFMANN-LA ROCHE AG (CH) | 2014-04-24 | — | — | WO | disclosed |
| WO-2014060371-A1 | INHIBITORS OF SYK | F. HOFFMANN-LA ROCHE AG (CH) | 2014-04-24 | — | — | WO | disclosed |
| WO-2013104573-A1 | PYRIDAZINE AMIDE COMPOUNDS AND THEIR USE AS SYK INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2013-07-18 | — | — | WO | disclosed |
| WO-2013104573-A1 | PYRIDAZINE AMIDE COMPOUNDS AND THEIR USE AS SYK INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2013-07-18 | — | — | WO | disclosed |
| US-20130178478-A1 | PYRIDAZINE AMIDE COMPOUNDS | HOFFMAN-LA ROCHE INC. (US) | 2013-07-11 | — | — | US | disclosed |
| US-20130178478-A1 | PYRIDAZINE AMIDE COMPOUNDS | HOFFMAN-LA ROCHE INC. (US) | 2013-07-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130178478-A1 | PYRIDAZINE AMIDE COMPOUNDS | SYK, BTK, IRAK2 | MEN1 4080/4885KMT2A 916/4885TDP1 476/4885 |
| US-20150284367-A1 | INHIBITORS OF SYK | SYK, BTK, LYN | MEN1 3657/4885KMT2A 898/4885TDP1 560/4885 |
| US-10112928-B2 | Inhibitors of SYK | SYK, BTK, LYN | MEN1 3657/4885KMT2A 898/4885TDP1 560/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.