Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 1/20 | 0.37 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | THRA | P10827 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | ACACB | O00763 | 1/20 | 0.35 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 2/20 | 0.35 |
| ▸ | PPARA | Q07869 | 2/20 | 0.35 |
| ▸ | PTGES | O14684 | 2/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | PPARD | Q03181 | 1/20 | 0.34 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1509456 | 0.90 | MAPK8 (0.38) | MAPK8MAPK10MAPTTP53SMN1; SMN2 | |
| SCHEMBL1509419 | 0.87 | AKR1C3 (0.37) | MAPK8MAPK10MAPTTP53SMN1; SMN2 | |
| SCHEMBL1509421 | 0.86 | ACACB (0.37) | MAPK8MAPK10MAPTTP53SMN1; SMN2 | |
| SCHEMBL1436505 | 0.85 | PPARG (0.42) | MAPTTP53SMN1; SMN2THRATHRB | |
| SCHEMBL1509439 | 0.85 | PTGES (0.41) | MAPK8MAPK10MAPTTP53SMN1; SMN2 | |
| SCHEMBL1509213 | 0.83 | PPARG (0.39) | MAPTTP53SMN1; SMN2THRATHRB | |
| SCHEMBL1436617 | 0.82 | AKR1C3 (0.44) | MAPTTP53SMN1; SMN2THRATHRB | |
| SCHEMBL1509404 | 0.82 | ACACB (0.34) | MAPK8MAPK10MAPTTP53SMN1; SMN2 | |
| SCHEMBL1436359 | 0.81 | PPARG (0.37) | MAPK8MAPK10MAPTTP53SMN1; SMN2 | |
| SCHEMBL1436724 | 0.81 | PPARG (0.41) | MAPTTP53SMN1; SMN2THRATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011026024-A2 | IMIDAZO [4,5-D] PYRIDAZINE COMPOUNDS FOR TREATING VIRAL INFECTIONS | GLAXOSMITHKLINE LLC (US) | 2011-03-03 | — | — | WO | claimed |
| WO-2011026024-A2 | IMIDAZO [4,5-D] PYRIDAZINE COMPOUNDS FOR TREATING VIRAL INFECTIONS | GLAXOSMITHKLINE LLC (US) | 2011-03-03 | — | — | WO | disclosed |