Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV6 | Q9H1D0 | 2/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27858737 | 0.78 | RECQL (0.32) | TSHRHTTSMN1; SMN2 | |
| SCHEMBL20267847 | 0.71 | MCL1 (0.36) | GAA | |
| SCHEMBL27992891 | 0.62 | POLB (0.32) | — | |
| SCHEMBL27540147 | 0.62 | MAOA (0.35) | GAA | |
| SCHEMBL27893678 | 0.62 | POLB (0.32) | — | |
| SCHEMBL27521248 | 0.62 | POLB (0.33) | — | |
| SCHEMBL27791970 | 0.62 | NOTUM (0.39) | TSHR | |
| SCHEMBL276521 | 0.61 | ALDH1A1 (0.34) | GAASMN1; SMN2 | |
| Bromide SCHEMBL27702376 | 0.61 | MAOA (0.34) | GAA | |
| SCHEMBL27991314 | 0.60 | SLC6A2 (0.33) | SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3148995-A1 | 6-SUBSTITUTED-3H-1,3-BENZOTHIAZOL-2-ONE COMPOUNDS AS TARP-GAMMA 8 DEPENDENT AMPA RECEPTOR ANTAGONISTS | Eli Lilly and Company (US) | 2017-04-05 | — | — | EP | disclosed |
| WO-2015183673-A1 | 6-SUBSTITUTED-3H-1,3-BENZOTHIAZOL-2-ONE COMPOUNDS AS TARP-GAMMA 8 DEPENDENT AMPA RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2015-12-03 | — | — | WO | disclosed |
| EP-2800747-A1 | POLYMORPHS OF PERAMPANEL | Mapi Pharma Limited (IL) | 2014-11-12 | — | — | EP | disclosed |
| WO-2013102897-A1 | POLYMORPHS OF PERAMPANEL | MAPI PHARMA LTD. (IL) | 2013-07-11 | — | — | WO | disclosed |