Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | PGR | P06401 | 1/20 | 0.36 |
| ▸ | RORA | P35398 | 1/20 | 0.36 |
| ▸ | RORC | P51449 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2553283 | 0.84 | SMN1; SMN2 (0.53) | ALDH1A1KMT2AKDM4ESMN1; SMN2POLB | |
| Hydrochloric Acid SCHEMBL2550119 | 0.82 | SMN1; SMN2 (0.51) | ALDH1A1KMT2AKDM4ESMN1; SMN2POLB | |
| Hydrochloric Acid SCHEMBL2550919 | 0.77 | KMT2A (0.53) | LMNAPKMALDH1A1KMT2AKDM4E | |
| SCHEMBL27772278 | 0.76 | LMNA (0.50) | LMNAPKMALDH1A1TSHRKMT2A | |
| SCHEMBL2553123 | 0.75 | GPR3 (0.50) | LMNAALDH1A1KMT2AKDM4ESMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL14672734 | 0.74 | GPR3 (0.48) | LMNAALDH1A1KMT2AKDM4ESMN1; SMN2 | |
| Bromide SCHEMBL16858710 | 0.74 | GPR3 (0.48) | LMNAALDH1A1KMT2AKDM4ESMN1; SMN2 | |
| SCHEMBL2549113 | 0.72 | KDM4E (0.47) | LMNAPKMALDH1A1KMT2AKDM4E | |
| Hydrochloric Acid SCHEMBL2553176 | 0.71 | KDM4E (0.46) | LMNAPKMALDH1A1KMT2AKDM4E | |
| Hydrochloric Acid SCHEMBL2571838 | 0.69 | KDM4E (0.52) | LMNAPKMALDH1A1TSHRKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8962648-B2 | Tricyclic compounds and PBK inhibitors containing the same | ONCOTHERAPY SCIENCE, INC. (JP) | 2015-02-24 | — | — | US | disclosed |
| US-20130178459-A1 | TRICYCLIC COMPOUNDS AND PBK INHIBITORS CONTAINING THE SAME | ONCOTHERAPY SCIENCE, INC. (JP) | 2013-07-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130178459-A1 | TRICYCLIC COMPOUNDS AND PBK INHIBITORS CONTAINING THE SAME | PBDC1, SBK1, PLK2 | LMNA 1265/4885PKM 338/4885ALDH1A1 4033/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.