Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA1 | P02708 | 4/20 | 0.34 |
| ▸ | CHRNG | P07510 | 4/20 | 0.34 |
| ▸ | CHRNB1 | P11230 | 4/20 | 0.34 |
| ▸ | CHRND | Q07001 | 4/20 | 0.34 |
| ▸ | TLR2 | O60603 | 4/20 | 0.34 |
| ▸ | CA2 | P00918 | 2/20 | 0.33 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.33 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.33 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.32 |
| ▸ | PRKACA | P17612 | 1/20 | 0.32 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | Q9HBH1 | 1/20 | 0.32 | |
| ▸ | CPB1 | P15086 | 1/20 | 0.31 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.31 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.31 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.31 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL1907045 | 0.78 | SSTR3 (0.34) | CA2CA1 | |
| Trifluoroacetic Acid SCHEMBL13387652 | 0.77 | CPB2 (0.40) | CA2CA1CPB2DDR1MAPK14 | |
| SCHEMBL13554877 | 0.77 | TLR2 (0.35) | CHRNA1CHRNGCHRNB1CHRNDTLR2 | |
| SCHEMBL1907701 | 0.71 | SMN1; SMN2 (0.36) | LMNA | |
| SCHEMBL13388273 | 0.71 | FURIN (0.31) | ||
| SCHEMBL13387526 | 0.69 | MAPT (0.35) | LMNAPOLB | |
| SCHEMBL1906671 | 0.68 | HDAC3 (0.38) | CA2CA1LMNA | |
| SCHEMBL20245010 | 0.63 | NMT1 (0.46) | TLR2SIRT1SIRT6NMT2NMT1 | |
| SCHEMBL21778353 | 0.62 | GLP1R (0.47) | TLR2SIRT1SIRT6ROCK2PRKACA | |
| SCHEMBL25386549 | 0.60 | SIRT1 (0.49) | CHRNA1CHRNGCHRNB1CHRNDTLR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8481494-B2 | Compounds for the treatment of diseases related to protein misfolding | UNIVERSITAT DUISBURG-ESSEN (DE) | 2013-07-09 | — | — | US | disclosed |