Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK10 | P53779 | 1/20 | 0.41 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | CA7 | P43166 | 2/20 | 0.39 |
| ▸ | CTSK | P43235 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | MIF | P14174 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 2/20 | 0.37 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.37 |
| ▸ | APLNR | P35414 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12571335 | 1.00 | MAPK10 (0.41) | MAPK10DGAT1TDP1CA1CA2 | |
| SCHEMBL8294662 | 0.88 | CTSK (0.43) | MAPK10DGAT1TDP1CA1CA2 | |
| SCHEMBL22433833 | 0.88 | MAPK10 (0.38) | MAPK10DGAT1TDP1CA1CA2 | |
| SCHEMBL8603435 | 0.88 | CTSK (0.43) | MAPK10DGAT1TDP1CA1CA2 | |
| SCHEMBL16938665 | 0.88 | MAPK10 (0.38) | MAPK10DGAT1TDP1CA1CA2 | |
| SCHEMBL8603431 | 0.88 | CTSK (0.43) | MAPK10DGAT1TDP1CA1CA2 | |
| SCHEMBL28354658 | 0.88 | MAPK10 (0.38) | MAPK10DGAT1TDP1CA1CA2 | |
| SCHEMBL6488438 | 0.86 | MAPK10 (0.37) | MAPK10DGAT1TDP1CA1CA2 | |
| SCHEMBL221182 | 0.86 | MAPK10 (0.37) | MAPK10DGAT1TDP1CA1CA2 | |
| SCHEMBL8035972 | 0.86 | MAPK10 (0.37) | MAPK10DGAT1TDP1CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8969573-B2 | Compounds for the inhibition of cellular proliferation | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2015-03-03 | — | — | US | disclosed |
| US-20130178505-A1 | Compounds for the Inhibition of Cellular Proliferation | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2013-07-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130178505-A1 | Compounds for the Inhibition of Cellular Proliferation | MKI67, EIF2AK2, CDK2 | MAPK10 721/4885DGAT1 1609/4885TDP1 1805/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.