Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.62 |
| ▸ | MAPT | P10636 | 3/20 | 0.62 |
| ▸ | AHR | P35869 | 1/20 | 0.58 |
| ▸ | SRC | P12931 | 7/20 | 0.54 |
| ▸ | EGFR | P00533 | 5/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 4/20 | 0.50 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15154427 | 0.91 | SRC (0.60) | SMN1; SMN2MAPTSRCEGFRALDH1A1 | |
| SCHEMBL15154174 | 0.90 | NPC1 (0.60) | SMN1; SMN2MAPTAHRSRCEGFR | |
| SCHEMBL15154482 | 0.89 | MAPT (0.59) | SMN1; SMN2MAPTAHRSRCEGFR | |
| SCHEMBL11983230 | 0.88 | SRC (0.64) | SMN1; SMN2MAPTAHRSRCEGFR | |
| SCHEMBL15154408 | 0.88 | NPC1 (0.62) | SMN1; SMN2MAPTSRCEGFRALDH1A1 | |
| SCHEMBL15154544 | 0.88 | AHR (0.56) | SMN1; SMN2MAPTAHRSRCEGFR | |
| SCHEMBL15154310 | 0.88 | SRC (0.51) | SMN1; SMN2MAPTSRCEGFRALDH1A1 | |
| SCHEMBL15154453 | 0.86 | ALDH1A1 (0.51) | SMN1; SMN2MAPTSRCEGFRALDH1A1 | |
| SCHEMBL15154493 | 0.85 | SMN1; SMN2 (0.55) | SMN1; SMN2MAPTAHRSRCEGFR | |
| SCHEMBL15154511 | 0.85 | MAPT (0.53) | SMN1; SMN2MAPTAHRSRCEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8962598-B2 | 1,2-dihydro-4-hydroxy-2-oxo-quinoline-3-carboxanilides as AHR activators | IMMUNAHR AB (SE) | 2015-02-24 | — | — | US | claimed |
| US-20130203703-A1 | 1,2-DIHYDRO-4-HYDROXY-2-OXO-QUINOLINE-3-CARBOXANILIDES AS AHR ACTIVATORS | IMMUNAHR AB (SE) | 2013-08-08 | — | — | US | claimed |
| US-8962598-B2 | 1,2-dihydro-4-hydroxy-2-oxo-quinoline-3-carboxanilides as AHR activators | IMMUNAHR AB (SE) | 2015-02-24 | — | — | US | disclosed |
| US-20130203703-A1 | 1,2-DIHYDRO-4-HYDROXY-2-OXO-QUINOLINE-3-CARBOXANILIDES AS AHR ACTIVATORS | IMMUNAHR AB (SE) | 2013-08-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130203703-A1 | 1,2-DIHYDRO-4-HYDROXY-2-OXO-QUINOLINE-3-CARBOXANILIDES AS AHR ACTIVATORS | AHR, HRH4, ARNT | SMN1; SMN2 4502/4885MAPT 4839/4885AHR 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.