Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15173039 | 0.92 | TBK1 (0.55) | TBK1IKBKE | |
| SCHEMBL15172931 | 0.89 | TBK1 (0.52) | TBK1IKBKE | |
| SCHEMBL15173157 | 0.87 | TBK1 (0.56) | TBK1IKBKE | |
| SCHEMBL15173033 | 0.85 | TBK1 (0.67) | TBK1IKBKE | |
| SCHEMBL18348025 | 0.85 | TBK1 (0.56) | TBK1IKBKE | |
| SCHEMBL18348024 | 0.84 | TBK1 (0.56) | TBK1IKBKE | |
| SCHEMBL15174761 | 0.84 | TBK1 (0.61) | TBK1IKBKE | |
| SCHEMBL15173325 | 0.84 | TBK1 (0.54) | TBK1IKBKE | |
| SCHEMBL16336236 | 0.84 | TBK1 (0.55) | TBK1IKBKE | |
| SCHEMBL15173112 | 0.83 | TBK1 (0.56) | TBK1IKBKE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2812337-B1 | FURO [3, 2 - B]PYRIDINE DERIVATIVES AS TBK1 AND IKK INHIBITORS | MERCK PATENT GMBH (DE) | 2016-09-07 | — | — | EP | claimed |
| US-9045493-B2 | Furo[3,2-b]- and thieno[3,2-b]pyridin derivatives | MERCK PATENT GMBH (DE) | 2015-06-02 | — | — | US | claimed |
| US-20150005284-A1 | Furo[3,2-b]- and thieno[3,2-b]pyridin derivatives | MERCK PATENT GMBH (DE) | 2015-01-01 | — | — | US | claimed |
| EP-2812337-A1 | FURO [3, 2 - B]- AND THIENO [3, 2 - B]PYRIDINE DERIVATIVES AS TBK1 AND IKK INHIBITORS | Merck Patent GmbH (DE) | 2014-12-17 | — | — | EP | claimed |
| WO-2013117285-A1 | FURO [3, 2 - B] - AND THIENO [3, 2 - B] PYRIDINE DERIVATIVES AS TBK1 AND IKK INHIBITORS | MERCK PATENT GMBH (DE) | 2013-08-15 | — | — | WO | claimed |
| EP-2812337-B1 | FURO [3, 2 - B]PYRIDINE DERIVATIVES AS TBK1 AND IKK INHIBITORS | MERCK PATENT GMBH (DE) | 2016-09-07 | — | — | EP | disclosed |
| US-9045493-B2 | Furo[3,2-b]- and thieno[3,2-b]pyridin derivatives | MERCK PATENT GMBH (DE) | 2015-06-02 | — | — | US | disclosed |
| US-20150005284-A1 | Furo[3,2-b]- and thieno[3,2-b]pyridin derivatives | MERCK PATENT GMBH (DE) | 2015-01-01 | — | — | US | disclosed |
| EP-2812337-A1 | FURO [3, 2 - B]- AND THIENO [3, 2 - B]PYRIDINE DERIVATIVES AS TBK1 AND IKK INHIBITORS | Merck Patent GmbH (DE) | 2014-12-17 | — | — | EP | disclosed |
| WO-2013117285-A1 | FURO [3, 2 - B] - AND THIENO [3, 2 - B] PYRIDINE DERIVATIVES AS TBK1 AND IKK INHIBITORS | MERCK PATENT GMBH (DE) | 2013-08-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150005284-A1 | Furo[3,2-b]- and thieno[3,2-b]pyridin derivatives | TBK1, NFKBIA, IKBKG | TBK1 1/4885IKBKE 12/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.