Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | FDFT1 | P37268 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | CPA1 | P15085 | 2/20 | 0.44 |
| ▸ | CPB1 | P15086 | 1/20 | 0.44 |
| ▸ | CPA3 | P15088 | 1/20 | 0.44 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.44 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
| ▸ | PPARA | Q07869 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1519959 | 1.00 | KMT2A (0.52) | KMT2AMEN1L3MBTL1ALDH1A1FDFT1 | |
| SCHEMBL1916688 | 0.87 | CPA1 (0.60) | CYP1A2CPA1CPB1CPA3CPB2 | |
| SCHEMBL1519838 | 0.87 | CPA1 (0.60) | CYP1A2CPA1CPB1CPA3CPB2 | |
| SCHEMBL1519833 | 0.87 | CPA1 (0.60) | CYP1A2CPA1CPB1CPA3CPB2 | |
| SCHEMBL27745166 | 0.87 | CYP3A4 (0.41) | KMT2AMEN1L3MBTL1ALDH1A1CYP3A4 | |
| SCHEMBL19377834 | 0.86 | MMP2 (0.48) | CPA1CPB1CPA3CPB2PPARG | |
| SCHEMBL19377835 | 0.86 | MMP2 (0.48) | CPA1CPB1CPA3CPB2PPARG | |
| SCHEMBL3664929 | 0.84 | KMT2A (0.59) | KMT2AMEN1L3MBTL1ALDH1A1FDFT1 | |
| SCHEMBL1519592 | 0.83 | PPARG (0.46) | CPA1CPB1CPA3CPB2PPARG | |
| SCHEMBL1519595 | 0.83 | PPARG (0.46) | CPA1CPB1CPA3CPB2PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7897619-B2 | Heterocyclic modulators of PKB | AMGEN INC. (US) | 2011-03-01 | — | — | US | disclosed |
| EP-2173728-A2 | HETEROCYCLIC MODULATORS OF PKB | Amgen Inc. (US) | 2010-04-14 | — | — | EP | disclosed |
| US-20090275592-A1 | Heterocyclic modulators of PKB | AMGEN INC. (US) | 2009-11-05 | — | — | US | disclosed |
| WO-2009011880-A2 | HETEROCYCLIC MODULATORS OF PKB | AMGEN INC. (US) | 2009-01-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090275592-A1 | Heterocyclic modulators of PKB | MTOR, PDK1, EIF4EBP1 | KMT2A 3140/4885MEN1 1764/4885L3MBTL1 3364/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.