Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | GCKR | Q14397 | 5/20 | 0.33 |
| ▸ | NR1H2 | P55055 | 6/20 | 0.33 |
| ▸ | NR1H3 | Q13133 | 6/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | MLYCD | O95822 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | CASP3 | P42574 | 1/20 | 0.30 |
| ▸ | PPARD | Q03181 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21437044 | 0.80 | KMT2A (0.33) | KMT2ANR1H2NR1H3 | |
| SCHEMBL12089520 | 0.80 | AR (0.37) | ARKMT2A | |
| SCHEMBL15202873 | 0.78 | NR1H2 (0.47) | GCKRNR1H2NR1H3MLYCD | |
| SCHEMBL30831236 | 0.78 | NR1H2 (0.34) | KMT2AGCKRNR1H2NR1H3L3MBTL1 | |
| SCHEMBL67213 | 0.77 | KMT2A (0.47) | KMT2AL3MBTL1MAPTTHRBCASP3 | |
| SCHEMBL17026 | 0.76 | AR (0.46) | ARNR1H2NR1H3MAPT | |
| SCHEMBL5199624 | 0.75 | GCK (0.46) | GCKRNR1H2NR1H3 | |
| SCHEMBL29480714 | 0.75 | GCK (0.46) | GCKRNR1H2NR1H3 | |
| SCHEMBL25100553 | 0.75 | FDFT1 (0.36) | KMT2A | |
| SCHEMBL28017609 | 0.74 | L3MBTL1 (0.33) | KMT2AL3MBTL1MAPTTHRBCASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013123444-A1 | SULFONYL COMPOUNDS THAT INTERACT WITH GLUCOKINASE REGULATORY PROTEIN | AMGEN INC. (US) | 2013-08-22 | — | — | WO | disclosed |
| WO-2013123444-A1 | SULFONYL COMPOUNDS THAT INTERACT WITH GLUCOKINASE REGULATORY PROTEIN | AMGEN INC. (US) | 2013-08-22 | — | — | WO | disclosed |