SCHEMBL28017609

SCHEMBL28017609

FC(F)(F)C(F)(c1ccc(Br)nc1)C(F)(F)F

nearest known ligand 0.33

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 2/20 0.33
MAPT P10636 1/20 0.33
KMT2A Q03164 1/20 0.32
THRB P10828 1/20 0.32
CHRNB2 P17787 2/20 0.32
CHRNA4 P43681 2/20 0.32
CASP3 P42574 1/20 0.31
TRPV1 Q8NER1 1/20 0.31
FDFT1 P37268 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL67213 0.82 KMT2A (0.47) L3MBTL1MAPTKMT2ATHRBCASP3
SCHEMBL15202873 0.79 NR1H2 (0.47)
SCHEMBL22735755 0.79 CHRNB2 (0.33) L3MBTL1MAPTKMT2ATHRBCHRNB2
SCHEMBL29480716 0.79 CHRNB2 (0.33) L3MBTL1MAPTKMT2ATHRBCHRNB2
SCHEMBL30831236 0.79 NR1H2 (0.34) L3MBTL1MAPTKMT2ATHRBCHRNB2
SCHEMBL1554553 0.78 MBOAT4 (0.33) L3MBTL1KMT2ATHRBCHRNB2CHRNA4
SCHEMBL29480714 0.76 GCK (0.46)
SCHEMBL5199624 0.76 GCK (0.46)
SCHEMBL21436992 0.75 KMT2A (0.34) KMT2ATHRBCHRNB2CHRNA4FDFT1
SCHEMBL25100553 0.75 FDFT1 (0.36) KMT2ACHRNB2CHRNA4FDFT1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-104803826-B A kind of method utilizing hexafluoropropene that aryl boric acid directly aoxidizes seven fluorine isopropylations 中国科学院上海有机化学研究所 2016-08-17 CN disclosed
CN-104803826-A Method for directly oxidizing arylboronic acid into heptafluoroisopropyl by utilizing hexafluoropropylene SHANGHAI INST ORGANIC CHEM 2015-07-29 CN disclosed