Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 3/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | ALPL | P05186 | 2/20 | 0.49 |
| ▸ | ALPG | P10696 | 2/20 | 0.49 |
| ▸ | ALPI | P09923 | 1/20 | 0.49 |
| ▸ | PLAA | Q9Y263 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | GFER | P55789 | 1/20 | 0.48 |
| ▸ | NOS1 | P29475 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | FDPS | P14324 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12693214 | 0.84 | KDM4E (0.51) | KDM4ETDP1POLBL3MBTL1GAA | |
| SCHEMBL315751 | 0.83 | KDM4E (0.50) | KDM4ETDP1POLBL3MBTL1GAA | |
| SCHEMBL15950980 | 0.79 | GRIN2B (0.50) | KDM4ETDP1POLBL3MBTL1GAA | |
| SCHEMBL12735399 | 0.78 | ALPL (0.54) | KDM4ETDP1POLBL3MBTL1GAA | |
| SCHEMBL369240 | 0.78 | ALPL (0.54) | KDM4ETDP1POLBL3MBTL1GAA | |
| SCHEMBL2960305 | 0.77 | ALPL (0.50) | KDM4ETDP1POLBL3MBTL1GAA | |
| SCHEMBL1179644 | 0.77 | ALPL (0.53) | KDM4ETDP1POLBL3MBTL1GAA | |
| SCHEMBL28938190 | 0.77 | ALPL (0.53) | KDM4ETDP1POLBL3MBTL1GAA | |
| Hydrochloric Acid SCHEMBL28835895 | 0.77 | ALPL (0.55) | KDM4ETDP1POLBL3MBTL1GAA | |
| SCHEMBL11173573 | 0.75 | SMN1; SMN2 (0.54) | KDM4ETDP1POLBL3MBTL1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013120559-A1 | USE OF ACYLHYDRAZONES AND THE PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF FOR PREVENTING THE DEVELOPMENT OF RESISTANCE OR REVERSING THE RESISTANCE OF TUMOURS TO CYTOSTATIC DRUGS | Ernst-Moritz-Arndt-Universität Greifswald (DE) | 2013-08-22 | — | — | WO | disclosed |