Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 2/20 | 0.47 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.47 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.47 |
| ▸ | P2RX7 | Q99572 | 5/20 | 0.46 |
| ▸ | SLC26A4 | O43511 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.44 |
| ▸ | LTK | P29376 | 1/20 | 0.44 |
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.44 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.44 |
| ▸ | FFAR1 | O14842 | 10/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | PPARD | Q03181 | 3/20 | 0.43 |
| ▸ | PPARG | P37231 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15211368 | 0.89 | NR4A2 (0.47) | NR4A2NR4A1NR4A3P2RX7SLC26A4 | |
| SCHEMBL17431514 | 0.88 | MMP1 (0.44) | NR4A2NR4A1NR4A3P2RX7SLC26A4 | |
| SCHEMBL17431460 | 0.87 | NR4A2 (0.53) | NR4A2NR4A1NR4A3SLC26A4POLB | |
| SCHEMBL15211783 | 0.87 | P2RX7 (0.48) | NR4A2NR4A1NR4A3P2RX7SLC26A4 | |
| SCHEMBL17431423 | 0.86 | NR4A2 (0.49) | NR4A2NR4A1NR4A3P2RX7SLC26A4 | |
| SCHEMBL15211732 | 0.85 | P2RX7 (0.45) | NR4A2NR4A1NR4A3P2RX7SLC26A4 | |
| SCHEMBL17431477 | 0.85 | FFAR1 (0.53) | NR4A2NR4A1NR4A3FFAR1PPARD | |
| SCHEMBL19191094 | 0.83 | CD274 (0.41) | FFAR1PPARDPPARG | |
| SCHEMBL17431270 | 0.82 | FFAR1 (0.46) | NR4A2NR4A1NR4A3P2RX7SLC26A4 | |
| SCHEMBL15220439 | 0.81 | FFAR1 (0.53) | NR4A2NR4A1NR4A3FFAR1PPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2838891-B1 | AROMATIC RING COMPOUND AS GHRELIN O-ACYLTRANSFERASE INHIBITOR | TAKEDA PHARMACEUTICALS CO (JP) | 2017-08-02 | — | — | EP | disclosed |
| US-9238639-B2 | Aromatic ring compound | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2016-01-19 | — | — | US | disclosed |
| US-9238639-B2 | Aromatic ring compound | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2016-01-19 | — | — | US | disclosed |
| US-9238639-B2 | Aromatic ring compound | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2016-01-19 | — | — | US | disclosed |
| EP-2838891-A1 | AROMATIC RING COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2015-02-25 | — | — | EP | disclosed |
| WO-2013125732-A1 | AROMATIC RING COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-08-29 | — | — | WO | disclosed |