Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | PGD | P52209 | 2/20 | 0.33 |
| ▸ | MME | P08473 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12672374 | 0.80 | PDE4A (0.43) | PDE4ATGFBR1TSHROR51E2CYP2C9 | |
| SCHEMBL10386274 | 0.80 | PDE4A (0.43) | PDE4ATGFBR1TSHROR51E2CYP2C9 | |
| SCHEMBL7963073 | 0.78 | PDE4A (0.38) | PDE4ATSHROR51E2CYP2C9PGD | |
| SCHEMBL7952614 | 0.78 | PDE4A (0.38) | PDE4ATSHROR51E2CYP2C9PGD | |
| SCHEMBL7953367 | 0.75 | MAPT (0.41) | PDE4ATSHROR51E2ALDH1A1 | |
| SCHEMBL9806490 | 0.72 | PDE4A (0.40) | PDE4ATGFBR1TSHROR51E2CYP2C9 | |
| SCHEMBL10386577 | 0.72 | PDE4A (0.40) | PDE4ATGFBR1TSHROR51E2CYP2C9 | |
| SCHEMBL3372433 | 0.71 | PDE4A (0.43) | PDE4ATSHROR51E2CYP2C9PGD | |
| SCHEMBL7964570 | 0.71 | PDE4A (0.35) | PDE4ATSHROR51E2CYP2C9 | |
| SCHEMBL6940585 | 0.70 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8318955-B2 | Process for preparing 2,4-dioxotetrahydrofuran-3-carboxylates | BAYER CROPSCIENCE AG (DE) | 2012-11-27 | — | — | US | disclosed |
| US-20110060147-A1 | Process for preparing 2,4-dioxotetrahydrofuran-3-carboxylates | BAYER CROPSCIENCE AG (DE) | 2011-03-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110060147-A1 | Process for preparing 2,4-dioxotetrahydrofuran-3-carboxylates | HDHD5, HACL2, IDUA | PDE4A 4292/4885TGFBR1 4121/4885TSHR 545/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.