Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | SYK | P43405 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 5/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.51 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.51 |
| ▸ | RELA | Q04206 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | FOS | P01100 | 1/20 | 0.51 |
| ▸ | JUN | P05412 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29897636 | 0.94 | MEN1 (0.64) | ALDH1A1TDP1POLBMEN1KMT2A | |
| SCHEMBL423187 | 0.94 | MEN1 (0.64) | ALDH1A1TDP1POLBMEN1KMT2A | |
| SCHEMBL4762536 | 0.87 | HTT (0.55) | POLBMEN1KMT2AHPGDKDM4E | |
| SCHEMBL24340549 | 0.84 | MAPT (0.55) | ALDH1A1TDP1POLBMEN1KMT2A | |
| SCHEMBL20649220 | 0.84 | MEN1 (0.63) | ALDH1A1TDP1POLBMEN1KMT2A | |
| SCHEMBL3278294 | 0.83 | MEN1 (0.61) | ALDH1A1TDP1POLBMEN1KMT2A | |
| SCHEMBL31148410 | 0.83 | MEN1 (0.61) | ALDH1A1TDP1POLBMEN1KMT2A | |
| SCHEMBL31148360 | 0.82 | ALDH1A1 (0.60) | ALDH1A1TDP1POLBMEN1KMT2A | |
| SCHEMBL13696640 | 0.82 | ALDH1A1 (0.60) | ALDH1A1TDP1POLBMEN1KMT2A | |
| SCHEMBL2908655 | 0.81 | RAB9A (0.56) | ALDH1A1POLBMEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2817308-A1 | PYRIDOPYRIMIDINONE INHIBITORS OF KINASES | AbbVie Inc. (US) | 2014-12-31 | — | — | EP | disclosed |
| WO-2013126656-A1 | PYRIDOPYRIMIDINONE INHIBITORS OF KINASES | ABBVIE INC. (US) | 2013-08-29 | — | — | WO | disclosed |