Sugi Predict

Sugi Predict / Compounds / SCHEMBL1628253

SCHEMBL1628253

SCHEMBL1628253

CCOC(=O)c1cnc(SC)nc1O

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MEN1 O00255 1/20 0.62
▸ KMT2A Q03164 1/20 0.62
▸ ALDH1A1 P00352 7/20 0.61
▸ TDP1 Q9NUW8 2/20 0.61
▸ POLB P06746 1/20 0.61
▸ SYK P43405 2/20 0.57
▸ MAPT P10636 5/20 0.56
▸ HPGD P15428 2/20 0.56
▸ KDM4E B2RXH2 1/20 0.54
▸ SMN1; SMN2 Q16637 4/20 0.54
▸ NFKB1 P19838 3/20 0.54
▸ NFKB2 Q00653 3/20 0.54
▸ RELA Q04206 3/20 0.54
▸ LMNA P02545 1/20 0.54
▸ FOS P01100 1/20 0.54
▸ JUN P05412 1/20 0.54
▸ MAPK1 P28482 2/20 0.53
▸ HTT P42858 1/20 0.53
▸ RAB9A P51151 4/20 0.50
▸ NPC1 O15118 3/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7024255 0.87 ALDH1A1 (0.55) MEN1KMT2AALDH1A1TDP1POLB
SCHEMBL423187 0.86 MEN1 (0.64) MEN1KMT2AALDH1A1TDP1POLB
SCHEMBL29897636 0.86 MEN1 (0.64) MEN1KMT2AALDH1A1TDP1POLB
SCHEMBL8397035 0.85 MEN1 (0.62) MEN1KMT2AALDH1A1TDP1POLB
SCHEMBL14799238 0.85 ALDH1A1 (0.72) MEN1KMT2AALDH1A1TDP1POLB
SCHEMBL5768489 0.85 MEN1 (0.66) MEN1KMT2AALDH1A1TDP1POLB
SCHEMBL24997336 0.84 MEN1 (0.61) MEN1KMT2AALDH1A1TDP1POLB
SCHEMBL31148410 0.84 MEN1 (0.61) MEN1KMT2AALDH1A1TDP1POLB
SCHEMBL29506595 0.84 MAPT (0.61) MEN1KMT2AALDH1A1TDP1POLB
SCHEMBL3278294 0.84 MEN1 (0.61) MEN1KMT2AALDH1A1TDP1POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 64 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114933567-B Preparation method of 2-methylthio-4-pyrimidinone 武汉工程大学 2023-07-11 — — CN claimed
CN-114933567-A Preparation method of 2-methylthio-4-pyrimidone 武汉工程大学 2022-08-23 — — CN claimed
WO-2015001567-A1 PROCESS FOR THE PREPARATION OF (S)-4-[(3-CHLORO-4-METHOXYBENZYL)AMINO]-2-[2- (HYDROXYMETHYL)-1-PYRROLIDINYL]-N-(2-PYRIMIDINYL METHYL-5-PYRIMIDINE CARBOXAMIDE MSN LABORATORIES PRIVATE LIMITED (IN) 2015-01-08 — — WO claimed
US-20250214963-A1 SULFONYL AMIDE DERIVATIVES FOR THE TREATMENT OF ABNORMAL CELL GROWTH PFIZER INC. 2025-07-03 — — US disclosed
US-20240109862-A1 SULFONYL AMIDE DERIVATIVES FOR THE TREATMENT OF ABNORMAL CELL GROWTH PFIZER INC. 2024-04-04 — — US disclosed
CN-117430591-A Synthesis method of avanafil 康普药业股份有限公司 2024-01-23 — — CN disclosed
CN-114933567-B Preparation method of 2-methylthio-4-pyrimidinone 武汉工程大学 2023-07-11 — — CN disclosed
CN-114933567-B Preparation method of 2-methylthio-4-pyrimidinone 武汉工程大学 2023-07-11 — — CN disclosed
WO-2023116779-A1 DIALKYNE COMPOUND AND USE THEREOF 上海艾力斯医药科技股份有限公司 2023-06-29 — — WO disclosed
WO-2023116779-A1 DIALKYNE COMPOUND AND USE THEREOF 上海艾力斯医药科技股份有限公司 2023-06-29 — — WO disclosed
CN-114933567-A Preparation method of 2-methylthio-4-pyrimidone 武汉工程大学 2022-08-23 — — CN disclosed
WO-2006071940-A2 ENZYME MODULATORS AND TREATMENTS DECIPHERA PHARMACEUTICALS, LLC (US) 2006-07-06 — — WO disclosed
EP-1673090-A1 FUSED-ARYL AND HETEROARYL DERIVATIVES AND METHODS OF THEIR USE Wyeth (US) 2006-06-28 — — EP disclosed
JP-2006076970-A METHOD FOR PRODUCTION OF 4-CHLORO-2-(METHYLTHIO)PYRIMIDINES AIR WATER CHEMICAL INC 2006-03-23 — — JP disclosed
EP-1223170-B1 PYRIMIDINE-5-CARBOXAMIDE COMPOUNDS, PROCESS FOR PRODUCING THE SAME AND USE THEREOF TAKEDA PHARMACEUTICAL (JP) 2005-12-28 — — EP disclosed
JP-2005336073-A METHOD FOR PRODUCING 4-CHLORO-5-ETHOXYCARBONYL-2-METHYLTHIOPYRIMIDINE AIR WATER CHEMICAL INC 2005-12-08 — — JP disclosed
WO-2005037283-A1 FUSED-ARYL AND HETEROARYL DERIVATIVES AND METHODS OF THEIR USE WYETH (US) 2005-04-28 — — WO disclosed
EP-1223170-A1 PYRIMIDINE-5-CARBOXAMIDE COMPOUNDS, PROCESS FOR PRODUCING THE SAME AND USE THEREOF Takeda Chemical Industries, Ltd. (JP) 2002-07-17 — — EP disclosed
US-4447422-A Penicillins and compositions containing them BEECHAM GROUP P.1.C. (GB) 1984-05-08 — — US disclosed
EP-0067610-A1 Penicillins, a process for their preparation and compositions containing them BEECHAM GROUP PLC (GB) 1982-12-22 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250214963-A1 SULFONYL AMIDE DERIVATIVES FOR THE TREATMENT OF ABNORMAL CELL GROWTH GPR119, INSR, LYAR MEN1 675/4885KMT2A 1327/4885ALDH1A1 1427/4885
US-20240109862-A1 SULFONYL AMIDE DERIVATIVES FOR THE TREATMENT OF ABNORMAL CELL GROWTH GPR119, INSR, LYAR MEN1 675/4885KMT2A 1327/4885ALDH1A1 1427/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.