Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 12/20 | 0.74 |
| ▸ | HDAC8 | Q9BY41 | 10/20 | 0.74 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.63 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.63 |
| ▸ | HPGD | P15428 | 1/20 | 0.63 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.63 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.63 |
| ▸ | MMP1 | P03956 | 1/20 | 0.62 |
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.56 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.56 |
| ▸ | HDAC4 | P56524 | 5/20 | 0.56 |
| ▸ | HDAC7 | Q8WUI4 | 5/20 | 0.56 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.56 |
| ▸ | HDAC10 | Q969S8 | 5/20 | 0.56 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.56 |
| ▸ | HDAC9 | Q9UKV0 | 5/20 | 0.56 |
| ▸ | HDAC5 | Q9UQL6 | 5/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13783978 | 0.99 | HDAC1 (0.77) | HDAC1HDAC8ALDH1A1CYP1A2HPGD | |
| SCHEMBL9365890 | 0.86 | ALDH1A1 (0.67) | HDAC1HDAC8ALDH1A1CYP1A2HPGD | |
| SCHEMBL3383312 | 0.85 | HDAC8 (1.00) | HDAC1HDAC8MMP1HDAC6HDAC3 | |
| SCHEMBL1521117 | 0.85 | HDAC8 (1.00) | HDAC1HDAC8MMP1HDAC6HDAC3 | |
| SCHEMBL9805770 | 0.84 | ALDH1A1 (0.65) | HDAC1HDAC8ALDH1A1CYP1A2HPGD | |
| SCHEMBL9805744 | 0.84 | ALDH1A1 (0.65) | HDAC1HDAC8ALDH1A1CYP1A2HPGD | |
| SCHEMBL10574043 | 0.84 | ALDH1A1 (0.68) | HDAC1HDAC8ALDH1A1CYP1A2HPGD | |
| SCHEMBL9805746 | 0.84 | CYP1A2 (0.83) | HDAC1HDAC8ALDH1A1CYP1A2HPGD | |
| SCHEMBL8570532 | 0.83 | CYP1A2 (0.67) | HDAC1HDAC8ALDH1A1CYP1A2HPGD | |
| SCHEMBL16672058 | 0.83 | ALDH1A1 (0.67) | HDAC1HDAC8ALDH1A1CYP1A2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0261759-B1 | AMIDO SUBSTITUTED NAPHTHALENE AND INTERMEDIATES THEREOF | ORTHO PHARMACEUTICAL CORPORATION (US) | 1991-04-17 | — | — | EP | claimed |
| EP-0261759-A2 | Amido substituted naphthalene and intermediates thereof | ORTHO PHARMACEUTICAL CORPORATION (US) | 1988-03-30 | — | — | EP | claimed |
| US-4681894-A | AMIDO SUBSTITUTED NAPHTHALENES, ANTIINFLAMMATORY AGENTS | ORTHO PHARMACEUTICAL CORPORATION (US) | 1987-07-21 | — | — | US | claimed |
| US-20160015693-A1 | METHODS AND COMPOUNDS FOR PREVENTING AND TREATING A TUMOUR | AGENCY SCIENCE TECH & RES (SG) | 2016-01-21 | — | — | US | disclosed |
| US-8969313-B2 | Methods and compounds for preventing and treating a tumour | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2015-03-03 | — | — | US | disclosed |
| US-20110053882-A1 | METHODS AND COMPOUNDS FOR PREVENTING AND TREATING A TUMOUR | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2011-03-03 | — | — | US | disclosed |
| EP-2217240-A1 | METHODS AND COMPOUNDS FOR PREVENTING AND TREATING A TUMOUR | Agency for Science, Technology And Research (SG) | 2010-08-18 | — | — | EP | disclosed |
| WO-2009058102-A1 | METHODS AND COMPOUNDS FOR PREVENTING AND TREATING A TUMOUR | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2009-05-07 | — | — | WO | disclosed |
| EP-0261759-B1 | AMIDO SUBSTITUTED NAPHTHALENE AND INTERMEDIATES THEREOF | ORTHO PHARMACEUTICAL CORPORATION (US) | 1991-04-17 | — | — | EP | disclosed |
| US-4814487-A | ANTIINFLAMMATORY | ORTHO PHARMACEUTICAL CORPORATION (US) | 1989-03-21 | — | — | US | disclosed |
| EP-0261759-A2 | Amido substituted naphthalene and intermediates thereof | ORTHO PHARMACEUTICAL CORPORATION (US) | 1988-03-30 | — | — | EP | disclosed |
| US-4681894-A | AMIDO SUBSTITUTED NAPHTHALENES, ANTIINFLAMMATORY AGENTS | ORTHO PHARMACEUTICAL CORPORATION (US) | 1987-07-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110053882-A1 | METHODS AND COMPOUNDS FOR PREVENTING AND TREATING A TUMOUR | HDAC1, CCAR2, HDAC11 | HDAC1 1/4885HDAC8 19/4885ALDH1A1 2080/4885 |
| US-20160015693-A1 | METHODS AND COMPOUNDS FOR PREVENTING AND TREATING A TUMOUR | HDAC1, HDAC11, CCAR2 | HDAC1 1/4885HDAC8 15/4885ALDH1A1 1634/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.