Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 7/20 | 0.60 |
| ▸ | DPP7 | Q9UHL4 | 5/20 | 0.60 |
| ▸ | DPP8 | Q6V1X1 | 4/20 | 0.60 |
| ▸ | DPP9 | Q86TI2 | 4/20 | 0.60 |
| ▸ | NOTUM | Q6P988 | 5/20 | 0.54 |
| ▸ | NAMPT | P43490 | 1/20 | 0.51 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.48 |
| ▸ | KHK | P50053 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | C1S | P09871 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL18214922 | 1.00 | DPP4 (0.60) | DPP4DPP7DPP8DPP9NOTUM | |
| Trifluoroacetic Acid SCHEMBL19642281 | 0.91 | DPP4 (0.55) | DPP4DPP7DPP8DPP9NOTUM | |
| SCHEMBL21628259 | 0.85 | NOTUM (0.55) | DPP4DPP7DPP8DPP9NOTUM | |
| SCHEMBL314421 | 0.85 | NOTUM (0.55) | DPP4DPP7DPP8DPP9NOTUM | |
| SCHEMBL8386956 | 0.85 | NOTUM (0.55) | DPP4DPP7DPP8DPP9NOTUM | |
| Hydrochloric Acid SCHEMBL30775632 | 0.84 | NOTUM (0.53) | DPP4DPP7DPP8DPP9NOTUM | |
| Hydrochloric Acid SCHEMBL30775623 | 0.84 | NOTUM (0.53) | DPP4DPP7DPP8DPP9NOTUM | |
| Trifluoroacetic Acid SCHEMBL4748972 | 0.83 | NOTUM (0.55) | DPP4DPP7DPP8DPP9NOTUM | |
| Trifluoroacetic Acid SCHEMBL3552142 | 0.83 | MAPT (0.49) | DPP4DPP7DPP8DPP9NOTUM | |
| Trifluoroacetic Acid SCHEMBL3555102 | 0.83 | MAPT (0.49) | DPP4DPP7DPP8DPP9NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2817295-A1 | SUBSTITUTED 5-AMINOTHIENO[2,3-C]PYRIDAZINE-6-CARBOXAMIDE ANALOGS AS POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 | Vanderbilt University (US) | 2014-12-31 | — | — | EP | disclosed |
| WO-2013126856-A1 | SUBSTITUTED 5-AMINOTHIENO[2,3-C]PYRIDAZINE-6-CARBOXAMIDE ANALOGS AS POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 | VANDERBILT UNIVERSITY (US) | 2013-08-29 | — | — | WO | disclosed |