Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 5/20 | 0.55 |
| ▸ | DPP4 | P27487 | 3/20 | 0.55 |
| ▸ | DPP8 | Q6V1X1 | 3/20 | 0.55 |
| ▸ | DPP9 | Q86TI2 | 3/20 | 0.55 |
| ▸ | DPP7 | Q9UHL4 | 3/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | MYC | P01106 | 2/20 | 0.43 |
| ▸ | WDR5 | P61964 | 2/20 | 0.43 |
| ▸ | RORC | P51449 | 3/20 | 0.42 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6398487 | 0.87 | NOTUM (0.59) | NOTUMDPP4RORC | |
| SCHEMBL3436548 | 0.87 | NOTUM (0.59) | NOTUMDPP4RORC | |
| SCHEMBL17392707 | 0.87 | NOTUM (0.59) | NOTUMDPP4RORC | |
| Trifluoroacetic Acid SCHEMBL15212493 | 0.83 | DPP4 (0.60) | NOTUMDPP4DPP8DPP9DPP7 | |
| Trifluoroacetic Acid SCHEMBL18214922 | 0.83 | DPP4 (0.60) | NOTUMDPP4DPP8DPP9DPP7 | |
| SCHEMBL16292723 | 0.81 | NOTUM (0.54) | NOTUMDPP4DPP8DPP9DPP7 | |
| Trifluoroacetic Acid SCHEMBL4749328 | 0.80 | DPP4 (0.60) | DPP4DPP8DPP9DPP7GPR119 | |
| Trifluoroacetic Acid SCHEMBL19642281 | 0.78 | DPP4 (0.55) | NOTUMDPP4DPP8DPP9DPP7 | |
| Pivalate SCHEMBL27800311 | 0.78 | GPR119 (0.54) | NOTUMMAPK1RORCGPR119 | |
| SCHEMBL6628944 | 0.76 | ALDH1A1 (0.53) | NOTUMRORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008121065-A1 | NOVEL PYRROLIDINE DERIVATIVES AS ANTAGONISTS OF THE CHEMOKINE RECEPTOR | ASTRAZENECA AB (SE) | 2008-10-09 | — | — | WO | disclosed |