Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GALR3 | O60755 | 1/20 | 0.38 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.38 |
| ▸ | DGAT1 | O75907 | 3/20 | 0.37 |
| ▸ | BRD4 | O60885 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | FABP4 | P15090 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | NPM1 | P06748 | 1/20 | 0.33 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | NQO2 | P16083 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29835911 | 0.96 | GALR3 (0.40) | GALR3NR2F2DGAT1BRD4MAPT | |
| SCHEMBL2144844 | 0.96 | GALR3 (0.40) | GALR3NR2F2DGAT1BRD4MAPT | |
| SCHEMBL13122602 | 0.86 | TDP1 (0.41) | GALR3NR2F2DGAT1BRD4MAPT | |
| SCHEMBL6019429 | 0.85 | DGAT1 (0.33) | GALR3NR2F2DGAT1BRD4MAPT | |
| SCHEMBL29985422 | 0.81 | KDM4E (0.45) | BRD4MAPTLMNAHSD17B10NPC1 | |
| SCHEMBL637860 | 0.80 | BRD4 (0.39) | GALR3NR2F2BRD4HSD17B10NPC1 | |
| SCHEMBL29991937 | 0.80 | ATM (0.47) | MAPTHSD17B10POLBNPC1ATM | |
| SCHEMBL10004078 | 0.80 | DGAT1 (0.39) | DGAT1MAPTLMNATSHRHSD17B10 | |
| SCHEMBL31709932 | 0.80 | TSHR (0.46) | DGAT1MAPTLMNATSHRHSD17B10 | |
| SCHEMBL30646682 | 0.79 | BRD4 (0.38) | DGAT1BRD4MAPTLMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2817310-A1 | 8 - SUBSTITUTED 2 -AMINO - [1,2,4]TRIAZOLO [1, 5 -A]PYRAZINES AS SYK TRYROSINE KINASE INHIBITORS AND GCN2 SERIN KINASE INHIBITORS | Merck Patent GmbH (DE) | 2014-12-31 | — | — | EP | disclosed |
| WO-2013124026-A1 | 8 - SUBSTITUTED 2 -AMINO - [1,2,4] TRIAZOLO [1, 5 -A] PYRAZINES AS SYK TRYROSINE KINASE INHIBITORS AND GCN2 SERIN KINASE INHIBITORS | MERCK PATENT GMBH (DE) | 2013-08-29 | — | — | WO | disclosed |