Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 13/20 | 0.62 |
| ▸ | CCRL2 | O00421 | 12/20 | 0.62 |
| ▸ | KCNH2 | Q12809 | 11/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12032679 | 1.00 | CCR2 (0.62) | CCR2CCRL2KCNH2 | |
| SCHEMBL12032553 | 0.91 | CCRL2 (0.62) | CCR2CCRL2KCNH2 | |
| SCHEMBL12033624 | 0.88 | CCRL2 (0.80) | CCR2CCRL2KCNH2 | |
| SCHEMBL12032669 | 0.87 | CCRL2 (0.60) | CCR2CCRL2KCNH2 | |
| SCHEMBL12032670 | 0.85 | CCR2 (0.62) | CCR2CCRL2KCNH2 | |
| SCHEMBL12032675 | 0.84 | CCRL2 (0.61) | CCR2CCRL2KCNH2 | |
| SCHEMBL12032672 | 0.84 | CCRL2 (0.60) | CCR2CCRL2KCNH2 | |
| SCHEMBL15214075 | 0.82 | CCRL2 (0.61) | CCR2CCRL2KCNH2 | |
| SCHEMBL12032681 | 0.82 | CCRL2 (0.61) | CCR2CCRL2KCNH2 | |
| SCHEMBL12032688 | 0.82 | CCRL2 (0.62) | CCR2CCRL2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8518969-B2 | Cyclohexyl-azetidinyl antagonists of CCR2 | JANSSEN PHARMACEUTICA NV (BE) | 2013-08-27 | — | — | US | disclosed |