Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR2 | O60603 | 6/20 | 0.47 |
| ▸ | TNF | P01375 | 2/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.37 |
| ▸ | MDM4 | O15151 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL801052 | 0.87 | CASP3 (0.43) | CASP3EPHX2KMT2AMDM2MDM4 | |
| SCHEMBL10045807 | 0.86 | HDAC1 (0.41) | TLR2TNFCASP3EPHX2KMT2A | |
| SCHEMBL13464731 | 0.76 | TLR2 (0.66) | TLR2TNFCASP3MDM2MDM4 | |
| SCHEMBL5574418 | 0.76 | TLR2 (0.66) | TLR2TNFCASP3MDM2MDM4 | |
| SCHEMBL16003008 | 0.76 | TLR2 (0.66) | TLR2TNFCASP3MDM2MDM4 | |
| SCHEMBL30517297 | 0.76 | TLR2 (0.66) | TLR2TNFCASP3MDM2MDM4 | |
| SCHEMBL14234630 | 0.75 | TLR2 (0.59) | TLR2TNFCASP3KMT2AMDM2 | |
| SCHEMBL765306 | 0.75 | TLR2 (0.55) | TLR2TNFCASP3KMT2AMDM2 | |
| SCHEMBL25356709 | 0.73 | TLR2 (0.70) | TLR2TNFCASP3MDM2MDM4 | |
| SCHEMBL25356714 | 0.73 | TLR2 (0.70) | TLR2TNFCASP3MDM2MDM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8518928-B2 | Therapeutic compounds | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2013-08-27 | — | — | US | disclosed |