Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 1/20 | 0.50 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.48 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.47 |
| ▸ | JAK2 | O60674 | 2/20 | 0.46 |
| ▸ | JAK1 | P23458 | 2/20 | 0.46 |
| ▸ | TYK2 | P29597 | 2/20 | 0.46 |
| ▸ | JAK3 | P52333 | 2/20 | 0.46 |
| ▸ | PIM1 | P11309 | 1/20 | 0.46 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.46 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.46 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.45 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.45 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11955380 | 0.86 | MAP4K4 (0.48) | MAP4K4S1PR1PIK3CAJAK2JAK1 | |
| SCHEMBL14320448 | 0.86 | MAP4K4 (0.53) | MAP4K4S1PR1PIK3CAJAK2JAK1 | |
| SCHEMBL11947309 | 0.85 | SIGMAR1 (0.52) | MAP4K4S1PR1PIK3CAJAK2JAK1 | |
| SCHEMBL10355225 | 0.85 | S1PR1 (0.56) | MAP4K4S1PR1PIK3CAJAK2JAK1 | |
| SCHEMBL18082578 | 0.84 | IRAK4 (0.47) | MAP4K4S1PR1PIK3CAJAK2JAK1 | |
| SCHEMBL22918727 | 0.83 | MAP4K4 (0.48) | MAP4K4S1PR1PIK3CAJAK2JAK1 | |
| SCHEMBL13354351 | 0.82 | CYP11B2 (0.53) | MAP4K4S1PR1PIK3CAJAK2JAK1 | |
| SCHEMBL6937374 | 0.82 | JAK2 (0.41) | S1PR1JAK2JAK1TYK2JAK3 | |
| SCHEMBL16054452 | 0.80 | PIM1 (0.51) | MAP4K4S1PR1PIK3CAPIM1PIM3 | |
| SCHEMBL22792519 | 0.79 | MAP4K4 (0.52) | MAP4K4S1PR1PIK3CAJAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655357-B1 | INDAZOLYL TRIAZOLE DERIVATIVES AS IRAK INHIBITORS | MERCK SERONO SA (CH) | 2016-06-22 | — | — | EP | disclosed |
| US-9067928-B2 | Compounds and methods of use | ABBVIE INC. (US) | 2015-06-30 | — | — | US | disclosed |
| EP-2376085-B1 | COMPOUNDS AND METHODS OF USE | GENENTECH INC (US) | 2014-02-26 | — | — | EP | disclosed |
| US-8518970-B2 | Compounds and methods of use | ABBVIE INC. (US) | 2013-08-27 | — | — | US | disclosed |