Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 6/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 3/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.40 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.40 |
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10359775 | 0.90 | LMNA (0.46) | LMNASMN1; SMN2MEN1KMT2ACYP1A2 | |
| SCHEMBL2478712 | 0.90 | LMNA (0.47) | LMNASMN1; SMN2MEN1KMT2ACYP1A2 | |
| SCHEMBL10176265 | 0.89 | LMNA (0.45) | LMNASMN1; SMN2MEN1KMT2ACYP1A2 | |
| SCHEMBL2475963 | 0.80 | EGFR (0.41) | LMNASMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL15214852 | 0.74 | LPAR2 (0.42) | LMNASMN1; SMN2MEN1KMT2ACYP1A2 | |
| SCHEMBL30092872 | 0.72 | PDE4A (0.50) | LMNASMN1; SMN2ALDH1A1KDM4EHTT | |
| SCHEMBL3930470 | 0.66 | FLT1 (0.52) | LMNASMN1; SMN2ALDH1A1KDM4EMAPK1 | |
| SCHEMBL6398916 | 0.66 | HRH1 (0.53) | MAPK1LPAR2 | |
| SCHEMBL22714899 | 0.65 | KDM4E (0.50) | LMNACYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL13102365 | 0.64 | HRH3 (0.50) | ALDH1A1KDM4EL3MBTL1MBTD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9067928-B2 | Compounds and methods of use | ABBVIE INC. (US) | 2015-06-30 | — | — | US | disclosed |
| US-8518970-B2 | Compounds and methods of use | ABBVIE INC. (US) | 2013-08-27 | — | — | US | disclosed |