Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR2 | Q9HBW0 | 3/20 | 0.42 |
| ▸ | CSNK2A2 | P19784 | 3/20 | 0.41 |
| ▸ | CSNK2B | P67870 | 3/20 | 0.41 |
| ▸ | CSNK2A1 | P68400 | 3/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | GRM1 | Q13255 | 3/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | CD38 | P28907 | 1/20 | 0.38 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15214864 | 0.88 | LPAR2 (0.40) | LPAR2MAPTALDH1A1CD38CYP17A1 | |
| SCHEMBL2477392 | 0.88 | MAPK1 (0.41) | LPAR2FGFR1MAPTMEN1KMT2A | |
| SCHEMBL10227131 | 0.86 | LPAR2 (0.41) | LPAR2CD38 | |
| SCHEMBL10176269 | 0.86 | LPAR2 (0.39) | LPAR2TP53ALDH1A1CD38CYP17A1 | |
| SCHEMBL27410321 | 0.78 | LPAR2 (0.51) | LPAR2MAPTPKM | |
| SCHEMBL2476576 | 0.75 | LMNA (0.43) | LPAR2CD38LMNASMN1; SMN2HTT | |
| SCHEMBL15214860 | 0.74 | LMNA (0.52) | LPAR2ATML3MBTL1MEN1KMT2A | |
| SCHEMBL30808044 | 0.71 | PDPK1 (0.48) | LPAR2CSNK2A2CSNK2BCSNK2A1GRM1 | |
| SCHEMBL22750924 | 0.69 | LMNA (0.51) | TP53GRM1FGFR1MAPTMEN1 | |
| SCHEMBL14478872 | 0.66 | FGFR1 (0.60) | CSNK2A2CSNK2BCSNK2A1FGFR1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8518970-B2 | Compounds and methods of use | ABBVIE INC. (US) | 2013-08-27 | — | — | US | disclosed |