Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR2 | Q9HBW0 | 7/20 | 0.40 |
| ▸ | CD38 | P28907 | 1/20 | 0.40 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.34 |
| ▸ | LPAR1 | Q92633 | 3/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | HTT | P42858 | 3/20 | 0.33 |
| ▸ | EGFR | P00533 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15214852 | 0.88 | LPAR2 (0.42) | LPAR2CD38CYP17A1LMNAHTT | |
| SCHEMBL2477392 | 0.87 | MAPK1 (0.41) | LPAR2CD38CYP17A1GPR119LMNA | |
| SCHEMBL10176269 | 0.85 | LPAR2 (0.39) | LPAR2CD38CYP17A1GPR119PDE4B | |
| SCHEMBL2476576 | 0.74 | LMNA (0.43) | LPAR2CD38LPAR1LMNAHTT | |
| SCHEMBL27410321 | 0.74 | LPAR2 (0.51) | LPAR2LPAR1MAPT | |
| SCHEMBL30808044 | 0.71 | PDPK1 (0.48) | LPAR2CYP17A1LMNAEGFRALDH1A1 | |
| SCHEMBL22750924 | 0.68 | LMNA (0.51) | LMNAHTTSMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL14478872 | 0.65 | FGFR1 (0.60) | LMNAHTTSMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL30715861 | 0.63 | PDE4B (0.51) | LPAR2CD38LPAR1PDE4BPDE7A | |
| SCHEMBL27409928 | 0.63 | PDE4B (0.51) | LPAR2CD38LPAR1PDE4BPDE7A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8518970-B2 | Compounds and methods of use | ABBVIE INC. (US) | 2013-08-27 | — | — | US | disclosed |