Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK9 | P50750 | 15/20 | 0.41 |
| ▸ | CDK7 | P50613 | 14/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.38 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.37 |
| ▸ | TTK | P33981 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1070192 | 0.85 | CDK7 (0.38) | CDK9CDK7ADRA2AADRA1DADRA1A | |
| SCHEMBL1070526 | 0.84 | CDK7 (0.38) | CDK9CDK7ADRA2AADRA1DADRA1A | |
| SCHEMBL1072883 | 0.79 | KCNN3 (0.54) | CDK9CDK7ALK | |
| SCHEMBL12364043 | 0.75 | PTK2 (0.42) | ALKHDAC1 | |
| SCHEMBL12364041 | 0.74 | ALK (0.59) | CDK9CDK7ALK | |
| SCHEMBL11916291 | 0.73 | ALK (0.61) | ALKTTK | |
| SCHEMBL12364046 | 0.73 | ALK (0.48) | ALK | |
| SCHEMBL3949151 | 0.72 | CDK7 (0.51) | CDK9CDK7ALKHDAC1 | |
| SCHEMBL12364037 | 0.72 | ALK (0.57) | ALK | |
| SCHEMBL12364040 | 0.71 | KMT2A (0.41) | ALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8518931-B2 | Compounds and compositions as kinase inhibitors | IRM LLC (BM) | 2013-08-27 | — | — | US | disclosed |