Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.59 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.47 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | TET3 | O43151 | 1/20 | 0.44 |
| ▸ | FBXL19 | Q6PCT2 | 1/20 | 0.44 |
| ▸ | CXXC5 | Q7LFL8 | 1/20 | 0.44 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.44 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.44 |
| ▸ | CXXC4 | Q9H2H0 | 1/20 | 0.44 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17222224 | 1.00 | AKR1C1 (0.59) | AKR1C1ALOX15OPRM1OPRL1HDAC4 | |
| SCHEMBL16111555 | 0.85 | ALOX15 (0.59) | AKR1C1ALOX15OPRM1OPRL1HDAC4 | |
| SCHEMBL15215646 | 0.84 | ALOX15 (0.46) | AKR1C1ALOX15OPRM1OPRL1HDAC4 | |
| SCHEMBL15215645 | 0.84 | ALOX15 (0.46) | AKR1C1ALOX15OPRM1OPRL1HDAC4 | |
| SCHEMBL349711 | 0.82 | TET3 (0.48) | OPRM1OPRL1HDAC4KMT2ATET3 | |
| SCHEMBL349710 | 0.82 | TET3 (0.48) | OPRM1OPRL1HDAC4KMT2ATET3 | |
| SCHEMBL15209466 | 0.82 | HSD11B1 (0.47) | AKR1C1KMT2AMAOBHSD11B1MEN1 | |
| SCHEMBL15209465 | 0.82 | HSD11B1 (0.47) | AKR1C1KMT2AMAOBHSD11B1MEN1 | |
| SCHEMBL14541574 | 0.82 | TET3 (0.48) | OPRM1OPRL1HDAC4KMT2ATET3 | |
| SCHEMBL1538400 | 0.82 | AKR1C1 (0.40) | AKR1C1ALOX15OPRM1OPRL1HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9687459-B2 | Aminocyclobutane derivatives, method for preparing same and the use thereof as drugs | PIERRE FABRE MEDICAMENT (FR) | 2017-06-27 | — | — | US | disclosed |
| US-20170065543-A1 | AMINOCYCLOBUTANE DERIVATIVES, METHOD FOR PREPARING SAME AND THE USE THEREOF AS DRUGS | PIERRE FABRE MEDICAMENT (FR) | 2017-03-09 | — | — | US | disclosed |
| US-9469601-B2 | Aminocyclobutane derivatives, method for preparing same and the use thereof as drugs | PIERRE FABRE MEDICAMENT (FR) | 2016-10-18 | — | — | US | disclosed |
| US-20150315132-A1 | AMINOCYCLOBUTANE DERIVATIVES, METHOD FOR PREPARING SAME AND THE USE THEREOF AS DRUGS | PIERRE FABRE MEDICAMENT (FR) | 2015-11-05 | — | — | US | disclosed |
| US-20130225615-A1 | 2-CYCLOQUINAZOLINE DERIVATIVES AND METHODS OF USE THEREOF | AMBIT BIOSCIENCES CORPORATION (US) | 2013-08-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150315132-A1 | AMINOCYCLOBUTANE DERIVATIVES, METHOD FOR PREPARING SAME AND THE USE THEREOF AS DRUGS | GRIN1, GRIN3A, GRM1 | AKR1C1 844/4885ALOX15 3568/4885OPRM1 52/4885 |
| US-20130225615-A1 | 2-CYCLOQUINAZOLINE DERIVATIVES AND METHODS OF USE THEREOF | JAK2, JAK3, TYK2 | AKR1C1 4664/4885ALOX15 2601/4885OPRM1 4228/4885 |
| US-20170065543-A1 | AMINOCYCLOBUTANE DERIVATIVES, METHOD FOR PREPARING SAME AND THE USE THEREOF AS DRUGS | GRIN1, GRIN3A, GRM1 | AKR1C1 844/4885ALOX15 3568/4885OPRM1 52/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.