Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.48 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.42 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA7 | P43166 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17327809 | 0.86 | HDAC9 (0.62) | AKR1C1HDAC9HDAC4OPRM1HSD11B1 | |
| SCHEMBL890180 | 0.83 | AKR1C1 (0.57) | AKR1C1HDAC9HDAC4OPRM1HSD11B1 | |
| SCHEMBL8106838 | 0.83 | AKR1C1 (0.63) | AKR1C1HDAC9HDAC4HSD11B1ALOX15 | |
| SCHEMBL1447883 | 0.82 | MEN1 (0.55) | AKR1C1HDAC4OPRM1HSD11B1OPRL1 | |
| SCHEMBL28304679 | 0.79 | AKR1C1 (0.48) | AKR1C1HDAC9HDAC4OPRM1HSD11B1 | |
| SCHEMBL3737199 | 0.79 | AKR1C1 (0.70) | AKR1C1HDAC4HSD11B1OPRD1CA12 | |
| SCHEMBL12928712 | 0.79 | AKR1C1 (0.64) | AKR1C1HDAC4HSD11B1OPRD1CA12 | |
| SCHEMBL25463734 | 0.78 | OPRM1 (0.47) | AKR1C1HDAC9HDAC4OPRM1HSD11B1 | |
| SCHEMBL1838291 | 0.78 | AKR1C1 (0.68) | AKR1C1HDAC4HSD11B1MEN1KMT2A | |
| SCHEMBL24663621 | 0.78 | AKR1C1 (0.52) | AKR1C1HDAC9HDAC4OPRM1HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130225615-A1 | 2-CYCLOQUINAZOLINE DERIVATIVES AND METHODS OF USE THEREOF | AMBIT BIOSCIENCES CORPORATION (US) | 2013-08-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130225615-A1 | 2-CYCLOQUINAZOLINE DERIVATIVES AND METHODS OF USE THEREOF | JAK2, JAK3, TYK2 | AKR1C1 4664/4885HDAC9 1492/4885HDAC4 2071/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.