Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | EGFR | P00533 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5501630 | 0.80 | LMNA (0.55) | LMNASMN1; SMN2GFERGAANPC1 | |
| SCHEMBL14214694 | 0.77 | LMNA (0.52) | LMNASMN1; SMN2GFERGAANPC1 | |
| SCHEMBL5341006 | 0.76 | NSD2 (0.45) | LMNASMN1; SMN2KMT2AKDM4EMAPT | |
| SCHEMBL4682243 | 0.74 | SMN1; SMN2 (0.48) | LMNASMN1; SMN2GAANPC1KMT2A | |
| SCHEMBL580815 | 0.72 | LMNA (0.59) | LMNASMN1; SMN2GFERGAANPC1 | |
| SCHEMBL31511093 | 0.70 | CES2 (0.44) | LMNASMN1; SMN2GAANPC1KMT2A | |
| SCHEMBL8750794 | 0.70 | CES2 (0.44) | LMNASMN1; SMN2GAANPC1KMT2A | |
| SCHEMBL29016460 | 0.70 | LMNA (0.61) | LMNASMN1; SMN2GFERGAAATM | |
| SCHEMBL4796093 | 0.70 | SMN1; SMN2 (0.38) | LMNASMN1; SMN2GFERGAAATM | |
| SCHEMBL950218 | 0.70 | LMNA (0.73) | LMNASMN1; SMN2GFERGAANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130226549-A1 | STRUCTURE-BASED FRAGMENT HOPPING FOR LEAD OPTIMIZATION AND IMPROVEMENT IN SYNTHETIC ACCESSIBILITY | TSENG, YUFENG J. (TW) | 2013-08-29 | — | — | US | disclosed |