Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 1/20 | 0.44 |
| ▸ | QPCT | Q16769 | 1/20 | 0.36 |
| ▸ | QPCTL | Q9NXS2 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | PSMB1 | P20618 | 2/20 | 0.34 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.34 |
| ▸ | MAOA | P21397 | 2/20 | 0.34 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.33 |
| ▸ | TNF | P01375 | 1/20 | 0.33 |
| ▸ | SUV39H2 | Q9H5I1 | 2/20 | 0.33 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2777878 | 0.69 | RPS6KB2 (0.44) | IDO1MAPTPDE4APDE4DALDH1A1 | |
| SCHEMBL15216010 | 0.67 | PSMB1 (0.34) | PSMB1PSMB5PSMB2PDE10ATNF | |
| SCHEMBL10651277 | 0.66 | TNF (0.41) | PSMB1PSMB5PSMB2PDE4APDE4D | |
| SCHEMBL13409741 | 0.66 | TNF (0.49) | MAPTPDE10APDE4APDE4DTNF | |
| SCHEMBL29702221 | 0.66 | LRRK2 (0.48) | MAPTPSMB1PSMB5PDE10APDE4A | |
| SCHEMBL31207123 | 0.65 | ALDH1A1 (0.43) | MAPTMAOAPDE10APDE4APDE4D | |
| SCHEMBL8315056 | 0.65 | TLR8 (0.45) | IDO1MAPTPDE10ASOS1ALDH1A1 | |
| SCHEMBL7413595 | 0.63 | MAPT (0.40) | MAPTMAOAPDE10APDE4APDE4D | |
| SCHEMBL11535971 | 0.63 | IDO1 (1.00) | IDO1QPCTQPCTLMAPTALDH1A1 | |
| SCHEMBL25020508 | 0.62 | IRAK4 (0.42) | PSMB1PSMB5PSMB2PDE10APDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2435433-B1 | (DIHYDRO)IMIDAZOISO[5,1-A]QUINOLINES AS FSH RECEPTOR AGONISTS FOR THE TREATMENT OF FERTILITY DISORDERS | MERCK SHARP & DOHME (NL) | 2013-08-28 | — | — | EP | disclosed |