Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.38 |
| ▸ | CDK9 | P50750 | 2/20 | 0.38 |
| ▸ | AOX1 | Q06278 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | P2RX3 | P56373 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL313267 | 1.00 | KMT2A (0.40) | KMT2AMEN1ALDH1A1L3MBTL1CCNT1 | |
| SCHEMBL15216135 | 0.89 | ALDH1A1 (0.37) | KMT2AMEN1ALDH1A1CCNT1CDK9 | |
| SCHEMBL10136705 | 0.89 | ALDH1A1 (0.37) | KMT2AMEN1ALDH1A1CCNT1CDK9 | |
| SCHEMBL608898 | 0.88 | ADAM17 (0.36) | KMT2AMEN1ALDH1A1CCNT1CDK9 | |
| SCHEMBL15216134 | 0.86 | RXFP1 (0.34) | KMT2AMEN1GAAMAPTHDAC1 | |
| SCHEMBL313534 | 0.86 | RXFP1 (0.34) | KMT2AMEN1GAAMAPTHDAC1 | |
| SCHEMBL608882 | 0.84 | HTR2A (0.34) | KMT2AMEN1ALDH1A1L3MBTL1CCNT1 | |
| SCHEMBL313630 | 0.83 | NPSR1 (0.32) | KMT2AMEN1GAA | |
| SCHEMBL15216138 | 0.83 | NPSR1 (0.32) | KMT2AMEN1GAA | |
| SCHEMBL14806631 | 0.82 | ADAM17 (0.30) | ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2250174-B1 | MACROCYCLIC SERINE PROTEASE INHIBITORS | IDENIX PHARMACEUTICALS INC (US) | 2013-08-28 | — | — | EP | disclosed |