Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 14/20 | 0.51 |
| ▸ | MAPK13 | O15264 | 11/20 | 0.51 |
| ▸ | MAPK12 | P53778 | 11/20 | 0.51 |
| ▸ | MAPK11 | Q15759 | 11/20 | 0.51 |
| ▸ | BRAF | P15056 | 5/20 | 0.45 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.44 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.44 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1521548 | 0.91 | MAPK14 (0.43) | MAPK14MAPK13MAPK12MAPK11BRAF | |
| SCHEMBL1521555 | 0.79 | MAPK14 (0.53) | MAPK14MAPK13MAPK12MAPK11BRAF | |
| SCHEMBL1521814 | 0.79 | MAPK14 (0.52) | MAPK14MAPK13MAPK12MAPK11BRAF | |
| SCHEMBL1521965 | 0.78 | MAPK14 (0.51) | MAPK14MAPK13MAPK12MAPK11BRAF | |
| SCHEMBL1521946 | 0.77 | ABL1 (0.52) | MAPK14MAPK13MAPK12MAPK11BRAF | |
| SCHEMBL1521734 | 0.76 | MAPK14 (0.51) | MAPK14MAPK13MAPK12MAPK11BRAF | |
| SCHEMBL1011086 | 0.73 | MAPK14 (0.70) | MAPK14MAPK13MAPK12MAPK11BRAF | |
| SCHEMBL1521722 | 0.72 | KCNJ6 (0.48) | MAPK14MAPK13MAPK12MAPK11BRAF | |
| SCHEMBL1521661 | 0.70 | KCNJ6 (0.47) | MAPK14MAPK13MAPK12MAPK11BRAF | |
| SCHEMBL1521906 | 0.70 | KCNJ6 (0.46) | MAPK14MAPK13MAPK12MAPK11BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7897762-B2 | Kinase inhibitors useful for the treatment of proliferative diseases | DECIPHERA PHARMACEUTICALS, LLC (US) | 2011-03-01 | — | — | US | claimed |