Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 15/20 | 0.43 |
| ▸ | MAPK13 | O15264 | 5/20 | 0.42 |
| ▸ | BRAF | P15056 | 1/20 | 0.41 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.41 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1521650 | 0.91 | MAPK14 (0.51) | MAPK14MAPK13BRAFMAPK12MAPK11 | |
| SCHEMBL1521545 | 0.78 | MAPK14 (0.43) | MAPK14MAPK13BRAFMAPK12MAPK11 | |
| SCHEMBL1521763 | 0.78 | ABL1 (0.43) | MAPK14MAPK13BRAFMAPK12MAPK11 | |
| SCHEMBL1521794 | 0.77 | MAPK14 (0.44) | MAPK14MAPK13BRAFMAPK12MAPK11 | |
| SCHEMBL1521807 | 0.76 | MAPK14 (0.43) | MAPK14MAPK13BRAFMAPK12MAPK11 | |
| SCHEMBL1521820 | 0.75 | FGFR4 (0.43) | MAPK14MAPK13BRAFMAPK12MAPK11 | |
| SCHEMBL1521574 | 0.74 | MAPK14 (0.41) | MAPK14MAPK13BRAFMAPK12MAPK11 | |
| SCHEMBL1521946 | 0.73 | ABL1 (0.52) | MAPK14MAPK13BRAFMAPK12MAPK11 | |
| SCHEMBL1521555 | 0.70 | MAPK14 (0.53) | MAPK14MAPK13BRAFMAPK12MAPK11 | |
| SCHEMBL1521806 | 0.70 | BRAF (0.46) | MAPK14MAPK13BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7897762-B2 | Kinase inhibitors useful for the treatment of proliferative diseases | DECIPHERA PHARMACEUTICALS, LLC (US) | 2011-03-01 | — | — | US | claimed |