Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 5/20 | 0.52 |
| ▸ | MAPK14 | Q16539 | 12/20 | 0.49 |
| ▸ | SRC | P12931 | 4/20 | 0.49 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.49 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.49 |
| ▸ | BRAF | P15056 | 3/20 | 0.49 |
| ▸ | RET | P07949 | 3/20 | 0.49 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.49 |
| ▸ | AXL | P30530 | 2/20 | 0.49 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.49 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.49 |
| ▸ | PTK2B | Q14289 | 2/20 | 0.49 |
| ▸ | DDR2 | Q16832 | 2/20 | 0.49 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.49 |
| ▸ | MAP4K5 | Q9Y4K4 | 2/20 | 0.49 |
| ▸ | PLK4 | O00444 | 1/20 | 0.49 |
| ▸ | ACOX3 | O15254 | 1/20 | 0.49 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.49 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.49 |
| ▸ | JAK2 | O60674 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1521944 | 0.81 | ABL1 (0.54) | ABL1MAPK14SRCMAPK11MAPK9 | |
| SCHEMBL1521650 | 0.77 | MAPK14 (0.51) | MAPK14MAPK11BRAFNTRK1NTRK3 | |
| SCHEMBL2079924 | 0.77 | ABL1 (0.72) | ABL1MAPK14SRCMAPK11MAPK9 | |
| SCHEMBL1521806 | 0.76 | BRAF (0.46) | MAPK14BRAFRETRAF1NTRK1 | |
| SCHEMBL2081895 | 0.75 | ABL1 (0.70) | ABL1MAPK14SRCMAPK11MAPK9 | |
| SCHEMBL5056298 | 0.75 | ABL1 (0.59) | ABL1MAPK14SRCMAPK11MAPK9 | |
| SCHEMBL12078769 | 0.74 | BRAF (0.66) | ABL1MAPK14SRCMAPK11MAPK9 | |
| Hydrochloric Acid SCHEMBL2026938 | 0.74 | BRAF (0.65) | ABL1MAPK14SRCMAPK11MAPK9 | |
| SCHEMBL2082233 | 0.74 | MAPK14 (0.70) | ABL1MAPK14SRCMAPK11MAPK9 | |
| SCHEMBL2082325 | 0.74 | ABL1 (0.75) | ABL1MAPK14SRCMAPK11MAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7897762-B2 | Kinase inhibitors useful for the treatment of proliferative diseases | DECIPHERA PHARMACEUTICALS, LLC (US) | 2011-03-01 | — | — | US | claimed |