Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 1/20 | 0.60 |
| ▸ | CA1 | P00915 | 1/20 | 0.60 |
| ▸ | CA2 | P00918 | 1/20 | 0.60 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.60 |
| ▸ | HTR2A | P28223 | 2/20 | 0.57 |
| ▸ | HTR2C | P28335 | 1/20 | 0.57 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | BCHE | P06276 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.49 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.48 |
| ▸ | MPO | P05164 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4851028 | 0.84 | MPO (0.64) | CA12CA1CA2CA14HTR2A | |
| SCHEMBL7281853 | 0.84 | CA12 (0.55) | CA12CA1CA2CA14HTR2A | |
| SCHEMBL31711441 | 0.83 | KDM4E (0.60) | HTR2AHTR2CGAABCHEALDH1A1 | |
| SCHEMBL8504183 | 0.83 | CA12 (0.63) | CA12CA1CA2CA14HTR2A | |
| SCHEMBL14768749 | 0.82 | CA12 (0.58) | CA12CA1CA2CA14HTR2A | |
| SCHEMBL11571903 | 0.81 | BCHE (0.66) | CA12CA1CA2CA14HTR2A | |
| SCHEMBL13801208 | 0.81 | CA12 (0.61) | CA12CA1CA2CA14HTR2A | |
| SCHEMBL17150039 | 0.78 | CA12 (0.61) | CA12CA1CA2CA14ALDH1A1 | |
| SCHEMBL13570066 | 0.77 | ALOX5 (0.60) | CA12CA1CA2CA14GAA | |
| SCHEMBL18183555 | 0.77 | CA12 (0.60) | CA12CA1CA2CA14TAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130225583-A1 | SUBSTITUTED AMINO-TRIAZOLYL PDE10 INHIBITORS | MERCK SHARP & DOHME CORP. | 2013-08-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130225583-A1 | SUBSTITUTED AMINO-TRIAZOLYL PDE10 INHIBITORS | PDE10A, PDE12, PDE4A | CA12 4095/4885CA1 3238/4885CA2 3479/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.