Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 1/20 | 0.72 |
| ▸ | GAA | P10253 | 10/20 | 0.54 |
| ▸ | MGAM | O43451 | 9/20 | 0.54 |
| ▸ | AMY1A | P0DUB6 | 9/20 | 0.54 |
| ▸ | SI | P14410 | 9/20 | 0.54 |
| ▸ | MGAM2 | Q2M2H8 | 9/20 | 0.54 |
| ▸ | SLC9A1 | P19634 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | F2 | P00734 | 2/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.52 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2732640 | 0.84 | DGAT1 (1.00) | DGAT1GAAMGAMAMY1ASI | |
| SCHEMBL15426052 | 0.81 | DGAT1 (0.61) | DGAT1GAAMGAMAMY1ASI | |
| SCHEMBL18526054 | 0.81 | DGAT1 (0.61) | DGAT1GAAMGAMAMY1ASI | |
| SCHEMBL1520814 | 0.81 | DGAT1 (0.72) | DGAT1GAAMGAMAMY1ASI | |
| SCHEMBL535054 | 0.81 | GAA (0.64) | DGAT1GAAMGAMAMY1ASI | |
| SCHEMBL29163194 | 0.81 | DGAT1 (0.61) | DGAT1GAAMGAMAMY1ASI | |
| SCHEMBL14362020 | 0.81 | DGAT1 (0.61) | DGAT1GAAMGAMAMY1ASI | |
| SCHEMBL21737729 | 0.80 | DGAT1 (0.66) | DGAT1GAAMGAMAMY1ASI | |
| SCHEMBL12282952 | 0.80 | DGAT1 (0.66) | DGAT1GAAMGAMAMY1ASI | |
| SCHEMBL9618160 | 0.79 | DGAT1 (0.70) | DGAT1GAAMGAMAMY1ASI |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130225583-A1 | SUBSTITUTED AMINO-TRIAZOLYL PDE10 INHIBITORS | MERCK SHARP & DOHME CORP. | 2013-08-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130225583-A1 | SUBSTITUTED AMINO-TRIAZOLYL PDE10 INHIBITORS | PDE10A, PDE12, PDE4A | DGAT1 1985/4885GAA 250/4885MGAM 3071/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.