Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 2/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3368590 | 0.81 | HCAR2 (0.46) | CYP11B1CYP11B2POLB | |
| SCHEMBL27896449 | 0.78 | POLB (0.42) | CYP11B1CYP11B2POLB | |
| SCHEMBL12598886 | 0.78 | HCAR2 (0.47) | CYP11B1CYP11B2CYP3A4 | |
| SCHEMBL22056068 | 0.78 | SMN1; SMN2 (0.42) | CYP11B1CYP11B2CYP3A4 | |
| SCHEMBL3372179 | 0.77 | HTT (0.46) | POLBCYP3A4 | |
| SCHEMBL27960127 | 0.77 | CYP11B1 (0.33) | CYP11B1CYP11B2POLBCYP3A4NAPRT | |
| SCHEMBL27770450 | 0.77 | CYP11B2 (0.40) | CYP11B1CYP11B2POLB | |
| SCHEMBL3372685 | 0.77 | HCAR2 (0.46) | — | |
| SCHEMBL12599364 | 0.74 | POLB (0.39) | CYP11B1CYP11B2POLBCYP3A4NAPRT | |
| SCHEMBL3371881 | 0.73 | PDCD1 (0.40) | CYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2631238-A1 | Spirocyclic inhibitors of serine proteases for the treatment of hcv infections | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-08-28 | — | — | EP | disclosed |