Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.42 |
| ▸ | HRH1 | P35367 | 3/20 | 0.39 |
| ▸ | HRH2 | P25021 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15224088 | 0.88 | SLC18A3 (0.47) | ALDH1A1TSHRSLC18A3HRH1HRH2 | |
| SCHEMBL8312795 | 0.82 | ALDH1A1 (0.55) | ALDH1A1TSHRSLC18A3HRH1HRH2 | |
| SCHEMBL7422727 | 0.81 | MEN1 (0.51) | ALDH1A1TSHRSLC18A3HRH1HRH2 | |
| SCHEMBL9328257 | 0.81 | — | — | |
| SCHEMBL20609092 | 0.81 | SLC18A3 (0.56) | ALDH1A1TSHRSLC18A3HRH1MEN1 | |
| SCHEMBL15223837 | 0.80 | SLC18A3 (0.50) | ALDH1A1TSHRSLC18A3HRH1KDM4E | |
| SCHEMBL9660752 | 0.79 | ALDH1A1 (0.52) | ALDH1A1SLC18A3HRH1HRH2 | |
| SCHEMBL8148114 | 0.78 | SLC18A3 (0.50) | ALDH1A1TSHRSLC18A3HRH1KDM4E | |
| SCHEMBL5308772 | 0.77 | TLR8 (0.42) | ALDH1A1TSHRHRH1HRH2 | |
| SCHEMBL21440365 | 0.77 | DRD2 (0.39) | ALDH1A1HRH1HRH2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170333567-A1 | Novel Conjugates of CC-1065 Analogs and Bifunctional Linkers | SYNTARGA BV (NL) | 2017-11-23 | — | — | US | disclosed |
| US-20170274090-A1 | Novel Conjugates of CC-1065 Analogs and Bifunctional Linkers | SYNTARGA BV (NL) | 2017-09-28 | — | — | US | disclosed |
| US-9629924-B2 | Conjugates of CC-1065 analogs and bifunctional linkers | SYNTARGA BV (NL) | 2017-04-25 | — | — | US | disclosed |
| US-20130224227-A1 | NOVEL CONJUGATES OF CC-1065 ANALOGS AND BIFUNCTIONAL LINKERS | BYONDIS B.V. (NL) | 2013-08-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170274090-A1 | Novel Conjugates of CC-1065 Analogs and Bifunctional Linkers | PCNA, DCLRE1A, CDC5L | ALDH1A1 2514/4885TSHR 2473/4885SLC18A3 930/4885 |
| US-20170333567-A1 | Novel Conjugates of CC-1065 Analogs and Bifunctional Linkers | PCNA, DCLRE1A, CDC5L | ALDH1A1 2514/4885TSHR 2473/4885SLC18A3 930/4885 |
| US-20130224227-A1 | NOVEL CONJUGATES OF CC-1065 ANALOGS AND BIFUNCTIONAL LINKERS | PCNA, DCLRE1A, CDC5L | ALDH1A1 2514/4885TSHR 2473/4885SLC18A3 930/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.