Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AHR | P35869 | 5/20 | 0.47 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.39 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.39 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.39 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.39 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.37 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.37 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.37 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.37 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.37 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.37 |
| ▸ | APP | P05067 | 2/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | DHFR | P00374 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2168967 | 0.85 | PTGS2 (0.44) | PTGS2PTGS1CYP3A4CYP11B2KMO | |
| SCHEMBL8491555 | 0.85 | PTGS2 (0.44) | AHRSCN9AHSD11B1PTGS2PTGS1 | |
| SCHEMBL13729515 | 0.81 | DYRK1A (0.41) | PTGS2PTGS1KMOALDH1A1RAB9A | |
| SCHEMBL433163 | 0.79 | CYP1A2 (0.38) | AHRPTGS2PTGS1KDM4EALDH1A1 | |
| SCHEMBL8524724 | 0.79 | AHR (0.47) | AHRCYP1B1PTGER1PTGER3PTGER2 | |
| SCHEMBL29033979 | 0.79 | AHR (0.53) | AHRCYP1B1PTGER1PTGER3PTGER2 | |
| SCHEMBL4650223 | 0.75 | EGLN2 (0.37) | AHRSCN9APTGS2PTGS1CYP11B2 | |
| SCHEMBL9788256 | 0.75 | PTGS2 (0.40) | PTGS2PTGS1ADORA1ALDH1A1RAB9A | |
| SCHEMBL7812113 | 0.74 | TAAR1 (0.41) | KDM4E | |
| SCHEMBL5182077 | 0.74 | PDK2 (0.36) | AHRHSD11B1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1781664-B1 | INHIBITORS OF VEGF RECEPTOR AND HGF RECEPTOR SIGNALING | METHYLGENE INC (CA) | 2013-09-04 | — | — | EP | disclosed |