Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA6 | P17658 | 3/20 | 0.57 |
| ▸ | KCNA3 | P22001 | 3/20 | 0.57 |
| ▸ | KCNA4 | P22459 | 3/20 | 0.57 |
| ▸ | KCNA5 | P22460 | 2/20 | 0.57 |
| ▸ | PKM | P14618 | 2/20 | 0.56 |
| ▸ | DAO | P14920 | 2/20 | 0.52 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.51 |
| ▸ | VIP | P01282 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 2/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.37 |
| ▸ | KCNA2 | P16389 | 1/20 | 0.36 |
| ▸ | NT5E | P21589 | 1/20 | 0.36 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15228546 | 1.00 | KCNA6 (0.57) | KCNA6KCNA3KCNA4KCNA5PKM | |
| SCHEMBL15243719 | 0.81 | KCNA6 (0.51) | KCNA6KCNA3KCNA4KCNA5PKM | |
| SCHEMBL14843672 | 0.80 | SMYD3 (0.49) | KCNA6KCNA3KCNA4KCNA5KMT2A | |
| SCHEMBL13036735 | 0.74 | KCNA6 (0.67) | KCNA6KCNA3KCNA4KCNA5PKM | |
| SCHEMBL7845382 | 0.74 | PKM (0.60) | KCNA6KCNA3KCNA4KCNA5PKM | |
| SCHEMBL21182348 | 0.73 | KCNA6 (1.00) | KCNA6KCNA3KCNA4KCNA5PKM | |
| SCHEMBL23952430 | 0.72 | CREBBP (0.67) | KCNA6KCNA3KCNA4KCNA5PKM | |
| SCHEMBL28746425 | 0.71 | CREBBP (0.60) | KCNA6KCNA3KCNA4KCNA5PKM | |
| Keramadine SCHEMBL11123414 | 0.70 | KCNA6 (0.64) | KCNA6KCNA3KCNA4KCNA5PKM | |
| Keramadine SCHEMBL11123417 | 0.70 | KCNA6 (0.64) | KCNA6KCNA3KCNA4KCNA5PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9394297-B2 | Amides as pim inhibitors | AMGEN INC. (US) | 2016-07-19 | — | — | US | disclosed |
| US-20150329538-A1 | AMIDES AS PIM INHIBITORS | AMGEN INC. (US) | 2015-11-19 | — | — | US | disclosed |
| WO-2014022752-A1 | MACROCYCLES AS PIM INHIBITORS | AMGEN INC. (US) | 2014-02-06 | — | — | WO | disclosed |
| WO-2013130660-A1 | AMIDES AS PIM INHIBITORS | AMGEN INC. (US) | 2013-09-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150329538-A1 | AMIDES AS PIM INHIBITORS | PIM1, PIM3, PIM2 | KCNA6 2073/4885KCNA3 1736/4885KCNA4 2908/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.