Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Clonidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A known ✓ | P08913 | 11/20 | 0.76 |
| ▸ | ADRA2B known ✓ | P18089 | 8/20 | 0.76 |
| ▸ | ADRA2C known ✓ | P18825 | 8/20 | 0.76 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.76 |
| ▸ | LMNA | P02545 | 4/20 | 0.76 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.76 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.76 |
| ▸ | NISCH | Q9Y2I1 | 3/20 | 0.76 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.76 |
| ▸ | HRH2 | P25021 | 2/20 | 0.76 |
| ▸ | MEN1 | O00255 | 1/20 | 0.76 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.76 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.76 |
| ▸ | HTR1A | P08908 | 1/20 | 0.76 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.76 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.76 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.76 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.76 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.76 |
| ▸ | SLC47A1 | Q96FL8 | 1/20 | 0.76 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Clonidine SCHEMBL5983 | 0.87 | ADRA2A (1.00) | ADRA2AADRA2BADRA2CADRA1ALMNA | |
| Clonidine SCHEMBL40752 | 0.85 | ADRA2A (1.00) | ADRA2AADRA2BADRA2CADRA1ALMNA | |
| Clonidine SCHEMBL9838990 | 0.85 | ADRA2A (0.97) | ADRA2AADRA2BADRA2CADRA1ALMNA | |
| Clonidine SCHEMBL613364 | 0.85 | ADRA2A (0.97) | ADRA2AADRA2BADRA2CADRA1ALMNA | |
| Clonidine SCHEMBL2231324 | 0.85 | ADRA2A (1.00) | ADRA2AADRA2BADRA2CADRA1ALMNA | |
| Clonidine SCHEMBL3137306 | 0.85 | ADRA2A (0.74) | ADRA2AADRA2BADRA2CADRA1ALMNA | |
| Clonidine SCHEMBL18050245 | 0.82 | ADRA2A (0.82) | ADRA2AADRA2BADRA2CADRA1ALMNA | |
| Stearic Acid SCHEMBL4344851 | 0.78 | ADRA2A (0.62) | ADRA2AADRA2BADRA2CADRA1ALMNA | |
| SCHEMBL29352531 | 0.78 | ADRA2A (0.81) | ADRA2AADRA2BADRA2CADRA1ALMNA | |
| SCHEMBL9920135 | 0.77 | ADRA2A (0.79) | ADRA2AADRA2BADRA2CADRA1ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2636408-B1 | PATCH | TOYO INK SC HOLDINGS CO LTD (JP) | 2018-04-25 | — | — | EP | disclosed |
| US-9173855-B2 | Patch | SEKISUI MEDICAL CO., LTD. (JP) | 2015-11-03 | — | — | US | disclosed |
| US-20130261572-A1 | PATCH | SEKISUI MEDICAL CO., LTD. (JP) | 2013-10-03 | — | — | US | disclosed |
| CN-103313710-A | Patch | SEKISUI MEDICAL CO LTD | 2013-09-18 | — | — | CN | disclosed |
| EP-2636408-A1 | PATCH | Sekisui Medical Co., Ltd. (JP) | 2013-09-11 | — | — | EP | disclosed |