Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Clonidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A known ✓ | P08913 | 12/20 | 0.97 |
| ▸ | ADRA2B known ✓ | P18089 | 8/20 | 0.97 |
| ▸ | ADRA2C known ✓ | P18825 | 8/20 | 0.97 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.97 |
| ▸ | LMNA | P02545 | 4/20 | 0.97 |
| ▸ | NISCH | Q9Y2I1 | 4/20 | 0.97 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.97 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.97 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.97 |
| ▸ | HRH2 | P25021 | 2/20 | 0.97 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.97 |
| ▸ | MEN1 | O00255 | 1/20 | 0.97 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.97 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.97 |
| ▸ | HTR1A | P08908 | 1/20 | 0.97 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.97 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.97 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.97 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.97 |
| ▸ | SLC47A1 | Q96FL8 | 1/20 | 0.97 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Clonidine SCHEMBL5983 | 0.98 | ADRA2A (1.00) | ADRA2AADRA2BADRA2CADRA1ALMNA | |
| Clonidine SCHEMBL2231324 | 0.97 | ADRA2A (1.00) | ADRA2AADRA2BADRA2CADRA1ALMNA | |
| Clonidine SCHEMBL613364 | 0.97 | ADRA2A (0.97) | ADRA2AADRA2BADRA2CADRA1ALMNA | |
| Clonidine SCHEMBL40752 | 0.97 | ADRA2A (1.00) | ADRA2AADRA2BADRA2CADRA1ALMNA | |
| Clonidine SCHEMBL18050245 | 0.89 | ADRA2A (0.82) | ADRA2AADRA2BADRA2CADRA1ALMNA | |
| SCHEMBL29352531 | 0.88 | ADRA2A (0.81) | ADRA2AADRA2BADRA2CADRA1ALMNA | |
| SCHEMBL12225936 | 0.87 | ADRA2A (0.79) | ADRA2AADRA2BADRA2CADRA1ALMNA | |
| SCHEMBL9920135 | 0.87 | ADRA2A (0.79) | ADRA2AADRA2BADRA2CADRA1ALMNA | |
| SCHEMBL11176814 | 0.87 | ADRA2A (0.79) | ADRA2AADRA2BADRA2CADRA1ALMNA | |
| Clonidine SCHEMBL15234061 | 0.85 | ADRA2A (0.76) | ADRA2AADRA2BADRA2CADRA1ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220211672-A1 | METHODS OF TREATING PRURITUS | CLEXIO BIOSCIENCES LTD. (IL) | 2022-07-07 | — | — | US | disclosed |
| WO-2020222192-A1 | METHODS OF TREATING PRURITUS | CLEXIO BIOSCIENCES LTD. (IL) | 2020-11-05 | — | — | WO | disclosed |
| WO-1991001715-A1 | OPHTHALMIC COMPOSITIONS | SMITH & NEPHEW PLC (GB) | 1991-02-21 | — | — | WO | disclosed |