Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 20/20 | 0.83 |
| ▸ | CYP3A4 | P08684 | 11/20 | 0.77 |
| ▸ | CYP2C9 | P11712 | 11/20 | 0.77 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.73 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL115468 | 1.00 | HSD11B1 (0.83) | HSD11B1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL115467 | 1.00 | HSD11B1 (0.83) | HSD11B1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL115466 | 1.00 | HSD11B1 (0.83) | HSD11B1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL13624883 | 0.91 | HSD11B1 (0.75) | HSD11B1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL116720 | 0.91 | HSD11B1 (1.00) | HSD11B1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL116719 | 0.91 | HSD11B1 (1.00) | HSD11B1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL116718 | 0.91 | HSD11B1 (1.00) | HSD11B1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL13638259 | 0.90 | HSD11B1 (0.73) | HSD11B1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL959240 | 0.88 | HSD11B1 (0.79) | HSD11B1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL955809 | 0.88 | HSD11B1 (0.79) | HSD11B1CYP3A4CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2324018-B1 | CYCLIC INHIBITORS OF 11 BETA-HYDROXYSTEROID DEHYDROGENASE 1 | BOEHRINGER INGELHEIM INT (DE) | 2013-09-04 | — | — | EP | disclosed |