Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 20/20 | 0.75 |
| ▸ | CYP2C9 | P11712 | 10/20 | 0.75 |
| ▸ | CYP3A4 | P08684 | 9/20 | 0.75 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.75 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL115466 | 0.91 | HSD11B1 (0.83) | HSD11B1CYP2C9CYP3A4CYP2C19 | |
| SCHEMBL13638259 | 0.91 | HSD11B1 (0.73) | HSD11B1CYP2C9CYP3A4CYP2C19 | |
| SCHEMBL115468 | 0.91 | HSD11B1 (0.83) | HSD11B1CYP2C9CYP3A4CYP2C19 | |
| SCHEMBL15241492 | 0.91 | HSD11B1 (0.83) | HSD11B1CYP2C9CYP3A4CYP2C19 | |
| SCHEMBL115467 | 0.91 | HSD11B1 (0.83) | HSD11B1CYP2C9CYP3A4CYP2C19 | |
| SCHEMBL13637093 | 0.90 | HSD11B1 (0.84) | HSD11B1CYP2C9CYP3A4CYP2C19 | |
| SCHEMBL14865110 | 0.89 | HSD11B1 (0.70) | HSD11B1CYP2C9CYP3A4CYP2C19 | |
| SCHEMBL955809 | 0.89 | HSD11B1 (0.79) | HSD11B1CYP2C9CYP3A4CYP2C19 | |
| SCHEMBL959240 | 0.89 | HSD11B1 (0.79) | HSD11B1CYP2C9CYP3A4CYP2C19 | |
| SCHEMBL955810 | 0.89 | HSD11B1 (0.79) | HSD11B1CYP2C9CYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2687525-B1 | CYCLIC INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | BOEHRINGER INGELHEIM INT (DE) | 2015-09-23 | — | — | EP | disclosed |
| WO-2009134400-A1 | CYCLIC INHIBITORS OF 11BETA-HYDROXYSTEROID DEHYDROGENASE 1 | VITAE PHARMACEUTICALS, INC. (US) | 2009-11-05 | — | — | WO | disclosed |