Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | BRAF | P15056 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | CDK8 | P49336 | 2/20 | 0.35 |
| ▸ | AXL | P30530 | 1/20 | 0.35 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.35 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.35 |
| ▸ | SGK1 | O00141 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 5/20 | 0.34 |
| ▸ | CLK1 | P49759 | 4/20 | 0.34 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.34 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.34 |
| ▸ | PLK4 | O00444 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13332909 | 0.83 | BRD4 (0.43) | BRD4MAPK1CDK8AXLTNIK | |
| SCHEMBL14032289 | 0.81 | MET (0.42) | BRAFAXLPDPK1PRMT5WDR77 | |
| SCHEMBL12762846 | 0.81 | CYP3A4 (0.48) | BRAFCYP2C9CYP2C19SGK1CYP3A4 | |
| SCHEMBL24005713 | 0.79 | PRMT5 (0.40) | BRAFCYP2C9CYP2C19AXLPDPK1 | |
| SCHEMBL20067661 | 0.78 | CYP3A4 (0.35) | CYP2C9CYP2C19AXLPDPK1SGK1 | |
| SCHEMBL19286222 | 0.77 | CYP3A4 (0.42) | CYP2C9CYP2C19SGK1CYP3A4CAMKK2 | |
| SCHEMBL22330343 | 0.77 | PDPK1 (0.36) | CYP2C9CYP2C19CDK8AXLTNIK | |
| SCHEMBL25139536 | 0.77 | AXL (0.33) | BRAFCYP2C19CDK8AXLTNIK | |
| SCHEMBL1045946 | 0.77 | BRD4 (0.54) | BRD4MAPK1CYP2C9CYP2C19CDK8 | |
| SCHEMBL31228005 | 0.77 | BRD4 (0.54) | BRD4MAPK1CYP2C9CYP2C19CDK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9873693-B2 | Methods of treatment using pyridinonyl PDK1 inhibitors | SUNESIS PHARMACEUTICALS, INC. (US) | 2018-01-23 | — | — | US | disclosed |