Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 10/20 | 0.56 |
| ▸ | DRD1 | P21728 | 7/20 | 0.56 |
| ▸ | DRD5 | P21918 | 6/20 | 0.56 |
| ▸ | DRD4 | P21917 | 5/20 | 0.56 |
| ▸ | DRD3 | P35462 | 5/20 | 0.56 |
| ▸ | DRD2 | P14416 | 5/20 | 0.56 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.44 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benproperine SCHEMBL29619460 | 0.99 | HRH1 (0.58) | HRH1DRD1DRD5DRD4DRD3 | |
| Benproperine SCHEMBL28016122 | 0.99 | HRH1 (0.58) | HRH1DRD1DRD5DRD4DRD3 | |
| Benproperine SCHEMBL17660555 | 0.99 | HRH1 (0.58) | HRH1DRD1DRD5DRD4DRD3 | |
| Benproperine SCHEMBL17660552 | 0.99 | HRH1 (0.58) | HRH1DRD1DRD5DRD4DRD3 | |
| Benproperine SCHEMBL142207 | 0.99 | HRH1 (0.58) | HRH1DRD1DRD5DRD4DRD3 | |
| Benproperine SCHEMBL15251665 | 0.97 | HRH1 (0.56) | HRH1DRD1DRD5DRD4DRD3 | |
| Benproperine SCHEMBL15251659 | 0.97 | HRH1 (0.56) | HRH1DRD1DRD5DRD4DRD3 | |
| Benproperine SCHEMBL28399849 | 0.97 | HRH1 (0.56) | HRH1DRD1DRD5DRD4DRD3 | |
| Benproperine SCHEMBL31351271 | 0.92 | HRH1 (0.51) | HRH1DRD1DRD5DRD4DRD3 | |
| Benproperine SCHEMBL348563 | 0.92 | HRH1 (0.51) | HRH1DRD1DRD5DRD4DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2638910-B1 | COMPOSITION COMPRISING BENPROPERINE DERIVATIVES AS ACTIVE INGREDIENTS FOR PREVENTING AND TREATING ANGIOGENESIS-RELATED DISEASES | KOREA RES INST BIOSCIENCE & BIOTECHNOLOGY (KR) | 2017-07-12 | — | — | EP | claimed |
| US-8716288-B2 | Composition comprising benproperine derivatives as active ingredients for preventing and treating angiogenesis-related diseases | KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY (KR) | 2014-05-06 | — | — | US | claimed |
| US-20130245068-A1 | COMPOSITION COMPRISING BENPROPERINE DERIVATIVES AS ACTIVE INGREDIENTS FOR PREVENTING AND TREATING ANGIOGENESIS-RELATED DISEASES | KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY (KR) | 2013-09-19 | — | — | US | claimed |
| EP-2638910-A2 | COMPOSITION COMPRISING BENPROPERINE DERIVATIVES AS ACTIVE INGREDIENTS FOR PREVENTING AND TREATING ANGIOGENESIS-RELATED DISEASES | Korea Research Institute of Bioscience and Biotechnology (KR) | 2013-09-18 | — | — | EP | claimed |
| EP-2638910-B1 | COMPOSITION COMPRISING BENPROPERINE DERIVATIVES AS ACTIVE INGREDIENTS FOR PREVENTING AND TREATING ANGIOGENESIS-RELATED DISEASES | KOREA RES INST BIOSCIENCE & BIOTECHNOLOGY (KR) | 2017-07-12 | — | — | EP | disclosed |
| US-8716288-B2 | Composition comprising benproperine derivatives as active ingredients for preventing and treating angiogenesis-related diseases | KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY (KR) | 2014-05-06 | — | — | US | disclosed |
| US-20130245068-A1 | COMPOSITION COMPRISING BENPROPERINE DERIVATIVES AS ACTIVE INGREDIENTS FOR PREVENTING AND TREATING ANGIOGENESIS-RELATED DISEASES | KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY (KR) | 2013-09-19 | — | — | US | disclosed |
| EP-2638910-A2 | COMPOSITION COMPRISING BENPROPERINE DERIVATIVES AS ACTIVE INGREDIENTS FOR PREVENTING AND TREATING ANGIOGENESIS-RELATED DISEASES | Korea Research Institute of Bioscience and Biotechnology (KR) | 2013-09-18 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130245068-A1 | COMPOSITION COMPRISING BENPROPERINE DERIVATIVES AS ACTIVE INGREDIENTS FOR PREVENTING AND TREATING ANGIOGENESIS-RELATED DISEASES | KDR, FLT4, FLT1 | HRH1 1827/4885DRD1 1940/4885DRD5 734/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.