Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | RECQL | P46063 | 1/20 | 0.52 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.41 |
| ▸ | PYGL | P06737 | 7/20 | 0.36 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.35 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.35 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.35 |
| ▸ | CHAT | P28329 | 1/20 | 0.35 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15229162 | 1.00 | ALDH1A1 (0.52) | ALDH1A1CYP3A4RECQLKCNA3PYGL | |
| SCHEMBL4085701 | 0.82 | ALDH1A1 (0.57) | ALDH1A1CYP3A4RECQLNFE2L2TRPA1 | |
| SCHEMBL2004806 | 0.82 | ALDH1A1 (0.57) | ALDH1A1CYP3A4RECQLPYGLGRIK1 | |
| SCHEMBL4085705 | 0.82 | ALDH1A1 (0.57) | ALDH1A1CYP3A4RECQLNFE2L2TRPA1 | |
| SCHEMBL3743993 | 0.82 | ALDH1A1 (0.57) | ALDH1A1CYP3A4RECQLPYGLGRIK1 | |
| SCHEMBL29373832 | 0.81 | NFE2L2 (0.39) | KCNA3PYGLGRIK1GRIK2NFE2L2 | |
| SCHEMBL2097219 | 0.81 | KCNA3 (0.39) | ALDH1A1KCNA3PYGLGRIK1GRIK2 | |
| SCHEMBL2097221 | 0.81 | KCNA3 (0.39) | ALDH1A1KCNA3PYGLGRIK1GRIK2 | |
| SCHEMBL16877158 | 0.81 | ALDH1A1 (0.38) | ALDH1A1KCNA3TRPA1MAPTMAPK1 | |
| SCHEMBL2092118 | 0.80 | ALDH1A1 (0.38) | ALDH1A1KCNA3PYGLGRIK1GRIK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3321262-B1 | SERINE/THREONINE KINASE INHIBITORS | ARRAY BIOPHARMA INC (US) | 2021-01-13 | — | — | EP | disclosed |
| EP-3321262-A1 | SERINE/THREONINE KINASE INHIBITORS | Array Biopharma, Inc. (US) | 2018-05-16 | — | — | EP | disclosed |
| US-20180127393-A1 | SERINE/THREONINE KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2018-05-10 | — | — | US | disclosed |
| EP-2820009-B1 | SERINE/THREONINE KINASE INHIBITORS | ARRAY BIOPHARMA INC (US) | 2018-01-31 | — | — | EP | disclosed |
| US-9708290-B2 | Serine/threonine kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2017-07-18 | — | — | US | disclosed |
| US-20160122316-A1 | SERINE/THREONINE KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2016-05-05 | — | — | US | disclosed |
| US-9259470-B2 | Serine/threonine kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2016-02-16 | — | — | US | disclosed |
| US-20140249127-A1 | SERINE/THREONINE KINASE INHIBITORS | GENENTECH, INC. (US) | 2014-09-04 | — | — | US | disclosed |
| US-8697715-B2 | Serine/threonine kinase inhibitors | ARRAY BIOPHARMA, INC. (US) | 2014-04-15 | — | — | US | disclosed |
| US-20130252934-A1 | SERINE/THREONINE KINASE INHIBITORS | GENENTECH, INC. (US) | 2013-09-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160122316-A1 | SERINE/THREONINE KINASE INHIBITORS | MAP3K1, MAP3K11, TTBK1 | ALDH1A1 3280/4885CYP3A4 4336/4885RECQL 3218/4885 |
| US-20140249127-A1 | SERINE/THREONINE KINASE INHIBITORS | MAP3K1, MAP3K11, TTBK1 | ALDH1A1 3280/4885CYP3A4 4336/4885RECQL 3218/4885 |
| US-20180127393-A1 | SERINE/THREONINE KINASE INHIBITORS | MAP3K1, MAP3K11, TTBK1 | ALDH1A1 3280/4885CYP3A4 4336/4885RECQL 3218/4885 |
| US-20130252934-A1 | SERINE/THREONINE KINASE INHIBITORS | MAP3K1, MAP3K11, TTBK1 | ALDH1A1 3280/4885CYP3A4 4336/4885RECQL 3218/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.